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    Cep192 centrosomal protein 192 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307347, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep192provided by RGD
    Official Full Name
    centrosomal protein 192provided by RGD
    Primary source
    RGD:1562797
    See related
    EnsemblRapid:ENSRNOG00000042879 AllianceGenome:RGD:1562797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Da1-6; Seh1l
    Summary
    Predicted to enable phosphatase binding activity. Predicted to be involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Predicted to act upstream of or within response to bacterium. Predicted to be located in centriole; pericentriolar material; and procentriole. Predicted to be part of procentriole replication complex. Orthologous to human CEP192 (centrosomal protein 192). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 99.6), Spleen (RPKM 69.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep192 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63643816..63728264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61373937..61458405)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63572084..63656302)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10 like 1 Neighboring gene uncharacterized LOC102552297 Neighboring gene SEH1-like nucleoporin Neighboring gene small nucleolar RNA SNORA33 Neighboring gene tubulin, alpha 1B, pseudogene 3 Neighboring gene uncharacterized LOC134482959 Neighboring gene low density lipoprotein receptor class A domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Cep192 is required for mitotic centrosome and spindle assembly. Gomez-Ferreria MA, et al. Curr Biol, 2007 Nov 20. PMID 17980596
    2. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. Haren L, et al. PLoS One, 2009 Jun 19. PMID 19543530, Free PMC Article
    3. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Zhu F, et al. Curr Biol, 2008 Jan 22. PMID 18207742
    4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome-templated microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in pericentriolar material IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in procentriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 192 kDa
    Names
    SEH1-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402401.1 → NP_001389330.1  centrosomal protein of 192 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6GJY4, F1M5W3
      Related
      ENSRNOP00000023145.9, ENSRNOT00000023145.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63643816..63728264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056984938.2 → XP_056840918.1  centrosomal protein of 192 kDa isoform X1

      UniProtKB/TrEMBL
      F1M5W3

    2. XM_063277311.1 → XP_063133381.1  centrosomal protein of 192 kDa isoform X2

      UniProtKB/TrEMBL
      F1M5W3

    3. XM_063277312.1 → XP_063133382.1  centrosomal protein of 192 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I6A567, F1M5W3
      Related
      ENSRNOP00000087087.1, ENSRNOT00000098718.2

    4. XM_056984939.2 → XP_056840919.1  centrosomal protein of 192 kDa isoform X1

      UniProtKB/TrEMBL
      F1M5W3

    5. XM_056984942.2 → XP_056840922.1  centrosomal protein of 192 kDa isoform X4

      UniProtKB/TrEMBL
      F1M5W3
    Nucleotide Protein Strain
    Heading Accession and Version

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