Insig1 insulin induced gene 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Insig1provided by RGD
Official Full Name: insulin induced gene 1provided by RGD
Primary source: RGD:708457
See related: EnsemblRapid:ENSRNOG00000006859 AllianceGenome:RGD:708457
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxysterol binding activity and protein sequestering activity. Involved in cellular response to insulin stimulus; response to estradiol; and response to fatty acid. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Biomarker of steatotic liver disease. Orthologous to human INSIG1 (insulin induced gene 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1052.8), Adrenal (RPKM 412.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (8049339..8057812, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (7315494..7323972, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (342302..350515)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest expression of hepatocyte Insig1/Insig2a and Crebh/Creb3l3 (cAMP responsive element-binding protein 3-like 3 protein) can be up-regulated by dietary factors (here, dietary supplementation with hypotriglyceridemic R-alpha-lipoic acid).
Title: Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.
INSIG-1 is decreased by insulin in liver and increased in fat.
Title: Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue.
Overexpression of Insig-1 protects beta cells against glucolipotoxicity via SREBP-1c.
Title: Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.

Submit: New GeneRIF Correction

General gene information

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Markers

Insig1 (e-PCR), detects polymorphism
- UniSTS:532555

PMC303355P1 (e-PCR)
- UniSTS:272504

RH128057 (e-PCR)
- UniSTS:211365

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SREBP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SREBP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in SREBP-SCAP complex retention in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in SREBP-SCAP complex retention in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to sterol	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cranial suture morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cargo loading into COPII-coated vesicle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to sterol depletion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sterol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SREBP-SCAP-Insig complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SREBP-SCAP-Insig complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-induced gene 1 protein

Names: INSIG-1; growth response protein (CL-6); immediate-early protein CL-6; insulin-induced growth response protein CL-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022392.2 → NP_071787.1 insulin-induced gene 1 protein

See identical proteins and their annotated locations for NP_071787.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q08755

UniProtKB/TrEMBL

A6KJL1

Related

ENSRNOP00000009233.4, ENSRNOT00000009233.8

Conserved Domains (1) summary

pfam07281
Location:69 → 249

INSIG; Insulin-induced protein (INSIG)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

8049339..8057812 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108310.2 → XP_038964238.1 insulin-induced gene 1 protein isoform X3

Conserved Domains (1) summary

pfam07281
Location:70 → 157

INSIG; Insulin-induced protein (INSIG)
XM_039108311.2 → XP_038964239.1 insulin-induced gene 1 protein isoform X4

Conserved Domains (1) summary

pfam07281
Location:1 → 103

INSIG; Insulin-induced protein (INSIG)
XM_063286658.1 → XP_063142728.1 insulin-induced gene 1 protein isoform X1
XM_063286659.1 → XP_063142729.1 insulin-induced gene 1 protein isoform X2