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    Snx18 sorting nexin 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx18provided by RGD
    Official Full Name
    sorting nexin 18provided by RGD
    Primary source
    RGD:1310367
    See related
    EnsemblRapid:ENSRNOG00000010971 AllianceGenome:RGD:1310367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Snag1
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; plasma membrane tubulation; and positive regulation of autophagosome assembly. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; extracellular exosome; and growth cone. Predicted to be active in plasma membrane and recycling endosome membrane. Orthologous to human SNX18 (sorting nexin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 184.1), Spleen (RPKM 158.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx18 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46965498..46991516, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (45232325..45258345, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (45454782..45480798, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485597 Neighboring gene uncharacterized LOC134485596 Neighboring gene uncharacterized LOC108349945 Neighboring gene heat shock protein family B (small) member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons. Nakazawa S, et al. J Histochem Cytochem, 2011 Feb. PMID 21339182, Free PMC Article
    2. SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane. Park J, et al. J Cell Sci, 2010 May 15. PMID 20427313
    3. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. Ma MP, et al. J Cell Sci, 2012 Sep 15. PMID 22718350
    4. Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. Knævelsrud H, et al. J Cell Biol, 2013 Jul 22. PMID 23878278, Free PMC Article
    5. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. Desrochers G, et al. J Biol Chem, 2017 Apr 14. PMID 28235806, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-18
    Names
    sorting nexin associated golgi protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107652.1 → NP_001101122.1  sorting nexin-18

      See identical proteins and their annotated locations for NP_001101122.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A6I5R6, D3ZZ38
      Related
      ENSRNOP00000063122.1, ENSRNOT00000066764.3
      Conserved Domains (3) summary
      cd07286
      Location:267 → 394
      PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
      cd07670
      Location:406 → 612
      BAR_SNX18; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18
      cd11897
      Location:4 → 58
      SH3_SNX18; Src Homology 3 domain of Sorting nexin 18

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      46965498..46991516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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