Lamc1 laminin subunit gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamc1provided by RGD
Official Full Name: laminin subunit gamma 1provided by RGD
Primary source: RGD:621052
See related: EnsemblRapid:ENSRNOG00000002680 AllianceGenome:RGD:621052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: B2e
Summary: Predicted to enable glycosphingolipid binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including hair follicle cell proliferation; hair follicle morphogenesis; and neuron differentiation. Predicted to act upstream of or within neuron projection development. Located in collagen-containing extracellular matrix. Part of laminin-1 complex. Orthologous to human LAMC1 (laminin subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 919.8), Muscle (RPKM 535.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (67924872..68051986, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (65374372..65501492, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (70656727..70783515, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage.
Title: LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage.
enhances expression of insulin, and promotes transdifferentiation of bone marrow mesenchymal stem cells into islet-like cells
Title: Transdifferentiation of Bone Marrow Mesenchymal Stem Cells into the Islet-Like Cells: the Role of Extracellular Matrix Proteins.
In the hippocampus, thalamus, and piriform cortex both vascular lminin and astrocytic GFAP expression are up regulated following kainic acid injection.
Title: Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates.
Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.
Title: Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.
Lamc1 transcription can be controlled after transcription initiation.
Title: Transcription of laminin gamma1 chain gene in rat mesangial cells: constitutive and inducible RNA polymerase II recruitment and chromatin states.
Culturing renal mesangial cells with high glucose or glucosamine stimulates laminin gamma1 subunit expression significantly.
Title: Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti-oxidant alpha-lipoic acid.
Diffusable CYP2E1-derived oxidative-stress mediators induce synthesis of laminin gamma 1 by increased Sp1-dependent transactivation in hepatic stellate cells.
Title: Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1.
bcn-1 element-dependent activation by cooperative action of transcription factor E3 and Smad proteins
Title: bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins.
Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1.
Title: Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128406 (e-PCR)
- UniSTS:211714

D13Rat28 (e-PCR)
- UniSTS:118312

Lamc1 (e-PCR), detects polymorphism
- UniSTS:256621

RH138458 (e-PCR)
- UniSTS:220545

RH143373 (e-PCR)
- UniSTS:232620

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables glycosphingolipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in hair cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hair follicle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hemidesmosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-10 complex	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit gamma-1

Names: laminin, gamma 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053966.3 → NP_446418.1 laminin subunit gamma-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ICU8, F1MAA7

Related

ENSRNOP00000003605.5, ENSRNOT00000003605.9

Conserved Domains (10) summary

smart00136
Location:42 → 282

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:933 → 978

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:552 → 676

LamB; Laminin B domain

smart00283
Location:1089 → 1300

MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)

cd00055
Location:980 → 1027

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cl21499
Location:1518 → 1588

SPX; Domain found in Syg1, Pho81, XPR1, and related proteins

pfam00053
Location:443 → 490

Laminin_EGF; Laminin EGF domain

pfam00261
Location:1355 → 1586

Tropomyosin; Tropomyosin

cl09111
Location:1416 → 1551

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl09176
Location:1048 → 1121

FlgN; FlgN protein