Dnase2 deoxyribonuclease 2, lysosomal [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnase2provided by RGD
Official Full Name: deoxyribonuclease 2, lysosomalprovided by RGD
Primary source: RGD:621457
See related: EnsemblRapid:ENSRNOG00000023830 AllianceGenome:RGD:621457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnase2a
Summary: Enables DNA endonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to act upstream of or within DNA catabolic process; enucleate erythrocyte differentiation; and regulation of immune response. Predicted to be located in lysosome. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 172.2), Lung (RPKM 152.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40149505..40152225, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23244656..23247376, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26022855..26025523)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation.
Title: The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables deoxyribonuclease II activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyribonuclease II activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease II activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic DNA fragmentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within enucleate erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: deoxyribonuclease-2-alpha

Names: DNase II alpha; acid DNase; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; lysosomal DNase II

NP_612548.1

EC 3.1.22.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.