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Src SRC proto-oncogene, non-receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 83805, updated on 27-Nov-2024

Summary

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Official Symbol: Srcprovided by RGD
Official Full Name: SRC proto-oncogene, non-receptor tyrosine kinaseprovided by RGD
Primary source: RGD:620795
See related: EnsemblRapid:ENSRNOG00000009495 AllianceGenome:RGD:620795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein kinase C binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to peptide hormone stimulus; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and synaptic membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 86.6), Lung (RPKM 78.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Src in Genome Data Viewer

Location:: 3q42

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (166511616..166559463)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (146091969..146139492)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (153547807..153595643)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system.
Title: Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system.
Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.
Title: Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.
The Na,K-ATPase-dependent Src kinase signaling changes with mesenteric artery diameter.
Title: The Na,K-ATPase-Dependent Src Kinase Signaling Changes with Mesenteric Artery Diameter.
To explore the underlying mechanism, a rat model of renal interstitial fibrosis was established, then we observed obvious hypoxia in fibrotic kidney tissue and the protein levels of phospho-Src and Caveolin-1 increased, while MMP-2 activity decreased.
Title: Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.
src-family kinases-mediated inflammatory response may be responsible for central sensitization and chronic pain after lumbar disc herniation.
Title: Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation.
show that the striatal-enriched protein tyrosine phosphatase (STEP) is recruited by Galphaq-coupled receptors, including the M1 muscarinic acetylcholine receptor (M1R), and opposes the Src tyrosine kinase-mediated increase in the function of NMDARs composed of GluN2A
Title: STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.
Reactive oxygen species and SrcFK activate RhoA via ARHGEF1 in pulmonary artery.
Title: ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.
This paper provides evidence that TGF-beta stimulates prolonged EGFR transactivation, which is dependent on c-Src tyrosine kinase (Src).
Title: Src-mediated ligand release-independent EGFR transactivation involves TGF-β-induced Smad3 activation in mesangial cells.
Our findings demonstrate that Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc-dependent Cx43 tyrosine phosphorylation.
Title: Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase-dependent connexin43 phosphorylation.
In contrast to Na/K-ATPase alpha1, alpha3 could not regulate Src. Upon exposure to ouabain, Src activation did not occur, yet ERK was activated through Src-independent pathways involving PI3K and PKC. Hence, alpha3 expression confers signaling and pumping properties that are clearly distinct from that of cells expressing Na/K-ATPase alpha1.
Title: Src-independent ERK signaling through the rat α3 isoform of Na/K-ATPase.

Submit: New GeneRIF Correction See all GeneRIFs (124)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Src (e-PCR), detects polymorphism
- UniSTS:144506

BE110190 (e-PCR)
- UniSTS:245194

WI-14593 (e-PCR)
- UniSTS:44757

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables connexin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	TAS Traceable Author Statement more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone resorption	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to progesterone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to prolactin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in myoblast proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin TRK receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within odontogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of outer hair cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary ovarian follicle growth	IMP Inferred from Mutant Phenotype more info
involved_in progesterone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell projection assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mineralocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in podosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase Src

Names: Rous sarcoma oncogene; c-Src; p60-Src; pp60c-src; proto-oncogene c-Src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

NP_114183.1

EC 2.7.10.2

XP_017447555.1

EC 2.7.10.2

XP_017447557.1

EC 2.7.10.2

XP_017447560.1

EC 2.7.10.2

XP_038961885.1

EC 2.7.10.2

XP_038961886.1

EC 2.7.10.2

XP_038961888.1

EC 2.7.10.2

XP_038961889.1

EC 2.7.10.2

XP_038961890.1

EC 2.7.10.2

XP_038961891.1

EC 2.7.10.2

XP_038961892.1

EC 2.7.10.2

XP_038961893.1

EC 2.7.10.2

XP_038961894.1

EC 2.7.10.2

XP_063140734.1

EC 2.7.10.2

XP_063140735.1

EC 2.7.10.2

XP_063140736.1

EC 2.7.10.2

XP_063140737.1

EC 2.7.10.2

XP_063140738.1

EC 2.7.10.2

XP_063140739.1

EC 2.7.10.2

XP_063140740.1

EC 2.7.10.2

XP_063140741.1

EC 2.7.10.2

XP_063140742.1

EC 2.7.10.2

XP_063140743.1

EC 2.7.10.2

XP_063140744.1

EC 2.7.10.2

XP_063140745.1

EC 2.7.10.2

XP_063140746.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431489.1 → NP_001418418.1 proto-oncogene tyrosine-protein kinase Src isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
NM_001431490.1 → NP_001418419.1 proto-oncogene tyrosine-protein kinase Src isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
NM_001431491.1 → NP_001418420.1 proto-oncogene tyrosine-protein kinase Src isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
NM_001431492.1 → NP_001418421.1 proto-oncogene tyrosine-protein kinase Src isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
NM_001431493.1 → NP_001418422.1 proto-oncogene tyrosine-protein kinase Src isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_031977.2 → NP_114183.1 proto-oncogene tyrosine-protein kinase Src isoform b

See identical proteins and their annotated locations for NP_114183.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9WUD9

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

166511616..166559463

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284671.1 → XP_063140741.1 proto-oncogene tyrosine-protein kinase Src isoform X2
XM_039105966.2 → XP_038961894.1 proto-oncogene tyrosine-protein kinase Src isoform X2

Related

ENSRNOP00000071837.2, ENSRNOT00000080516.3

Conserved Domains (3) summary

cd10365
Location:147 → 247

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 143

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:260 → 536

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_063284670.1 → XP_063140740.1 proto-oncogene tyrosine-protein kinase Src isoform X2
XM_063284664.1 → XP_063140734.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_039105962.2 → XP_038961890.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_063284666.1 → XP_063140736.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_063284665.1 → XP_063140735.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_039105964.2 → XP_038961892.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_017592066.3 → XP_017447555.1 proto-oncogene tyrosine-protein kinase Src isoform X1

UniProtKB/Swiss-Prot

Q9WUD9

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_039105957.2 → XP_038961885.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Related

ENSRNOP00000012739.3, ENSRNOT00000012739.6

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_063284668.1 → XP_063140738.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
XM_063284667.1 → XP_063140737.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_063284676.1 → XP_063140746.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
XM_039105961.2 → XP_038961889.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_063284672.1 → XP_063140742.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
XM_039105965.2 → XP_038961893.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_063284674.1 → XP_063140744.1 proto-oncogene tyrosine-protein kinase Src isoform X2
XM_017592068.3 → XP_017447557.1 proto-oncogene tyrosine-protein kinase Src isoform X1

UniProtKB/Swiss-Prot

Q9WUD9

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_039105958.2 → XP_038961886.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_039105960.2 → XP_038961888.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_063284673.1 → XP_063140743.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
XM_063284669.1 → XP_063140739.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
XM_063284675.1 → XP_063140745.1 proto-oncogene tyrosine-protein kinase Src isoform X2

UniProtKB/Swiss-Prot

G3V776, Q45QJ2, Q9JJ10, Q9WUD9
XM_017592071.3 → XP_017447560.1 proto-oncogene tyrosine-protein kinase Src isoform X1

UniProtKB/Swiss-Prot

Q9WUD9

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_039105963.2 → XP_038961891.1 proto-oncogene tyrosine-protein kinase Src isoform X1

Conserved Domains (3) summary

cd10365
Location:153 → 253

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 149

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:266 → 542

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src