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    Man2b2 mannosidase, alpha, class 2B, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Man2b2provided by RGD
    Official Full Name
    mannosidase, alpha, class 2B, member 2provided by RGD
    Primary source
    RGD:1308840
    See related
    EnsemblRapid:ENSRNOG00000056162 AllianceGenome:RGD:1308840
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-450
    Summary
    Enables alpha-mannosidase activity. Involved in mannose metabolic process. Predicted to be active in lysosome. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 156.5), Spleen (RPKM 134.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Man2b2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (78193797..78218802)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (73969079..73994089)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (78939959..78964961)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene protein phosphatase 2, regulatory subunit B, gamma Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene Morf4 family associated protein 1 Neighboring gene uncharacterized LOC134481777

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity. Haeuw JF, et al. Biochem J, 1994 Feb 1. PMID 8110182, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Potential readthrough

    Included gene: Mrfap1

    Homology

    Clone Names

    • MGC188563

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epididymis-specific alpha-mannosidase
    Names
    mannosidase 2, alpha B2
    NP_001128443.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134971.4 → NP_001128443.2  epididymis-specific alpha-mannosidase precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      B5DEJ3
      Related
      ENSRNOP00000074589.2, ENSRNOT00000078562.3
      Conserved Domains (2) summary
      PLN02701
      Location:27 → 792
      PLN02701; alpha-mannosidase
      cd10811
      Location:27 → 352
      GH38N_AMII_Epman_like; N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      78193797..78218802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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