Acss1 acyl-CoA synthetase short-chain family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acss1provided by RGD
Official Full Name: acyl-CoA synthetase short-chain family member 1provided by RGD
Primary source: RGD:1306246
See related: EnsemblRapid:ENSRNOG00000007102 AllianceGenome:RGD:1306246
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acas2l
Summary: Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 458.5), Heart (RPKM 410.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (159910809..159960748, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (139450383..139500325, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (146420346..146470293, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF389773 (e-PCR)
- UniSTS:245532

D3Rat148 (e-PCR), detects polymorphism
- UniSTS:227556

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables propionate-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process from acetate	IEA Inferred from Electronic Annotation more info
involved_in propionate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: acetyl-coenzyme A synthetase 2-like, mitochondrial

Names: acetyl-Coenzyme A synthetase 2 (AMP forming)-like

NP_001099994.1

EC 6.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106524.1 → NP_001099994.1 acetyl-coenzyme A synthetase 2-like, mitochondrial

See identical proteins and their annotated locations for NP_001099994.1

Status: PROVISIONAL

Source sequence(s)

CH474050

UniProtKB/TrEMBL

A6KHF6, D3ZZN3

Related

ENSRNOP00000009627.4, ENSRNOT00000009627.7

Conserved Domains (2) summary

cd05966
Location:57 → 660

ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

TIGR02188
Location:45 → 670

Ac_CoA_lig_AcsA; acetate--CoA ligase