U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Nrg1 neuregulin 1 [ Mus musculus (house mouse) ]

    Gene ID: 211323, updated on 13-Jan-2025

    Summary

    Official Symbol
    Nrg1provided by MGI
    Official Full Name
    neuregulin 1provided by MGI
    Primary source
    MGI:MGI:96083
    See related
    Ensembl:ENSMUSG00000062991 AllianceGenome:MGI:96083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GGF; HRG; Hgl; NDF; ARIA; SMDF; GGFII; HRGalpha; Pro-NRG1; 6030402G23Rik; D230005F13Rik
    Summary
    Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including ERBB signaling pathway; nervous system development; and postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including nervous system development; positive regulation of intracellular signal transduction; and regulation of macromolecule metabolic process. Located in several cellular components, including axon; neuromuscular junction; and plasma membrane. Is active in several cellular components, including GABA-ergic synapse; mossy fiber rosette; and synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebrovascular disease (multiple); neurodegenerative disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in whole brain E14.5 (RPKM 2.0), CNS E14 (RPKM 1.9) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nrg1 in Genome Data Viewer
    Location:
    8 A3; 8 18.75 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (32299493..33381858, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31807452..32891609, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21082 Neighboring gene STARR-seq mESC enhancer starr_21083 Neighboring gene predicted gene, 38572 Neighboring gene STARR-seq mESC enhancer starr_21084 Neighboring gene STARR-seq mESC enhancer starr_21085 Neighboring gene STARR-seq mESC enhancer starr_21086 Neighboring gene STARR-seq mESC enhancer starr_21087 Neighboring gene trimethylguanosine synthase homolog pseudogene Neighboring gene VISTA enhancer mm151 Neighboring gene predicted gene, 33223 Neighboring gene STARR-seq mESC enhancer starr_21088 Neighboring gene STARR-seq mESC enhancer starr_21089 Neighboring gene predicted gene, 26578 Neighboring gene STARR-seq mESC enhancer starr_21090 Neighboring gene STARR-seq mESC enhancer starr_21091 Neighboring gene predicted gene 8179 Neighboring gene STARR-seq mESC enhancer starr_21092 Neighboring gene predicted gene, 22140 Neighboring gene predicted gene, 53413 Neighboring gene STARR-seq mESC enhancer starr_21093 Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene STARR-seq mESC enhancer starr_21095 Neighboring gene STARR-seq mESC enhancer starr_21096 Neighboring gene STARR-seq mESC enhancer starr_21097 Neighboring gene predicted gene, 39155 Neighboring gene predicted gene, 33082 Neighboring gene predicted gene 3985 Neighboring gene STARR-seq mESC enhancer starr_21098 Neighboring gene predicted gene, 39156 Neighboring gene predicted gene, 33281

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ErbB-2 class receptor binding PubMed 
    enables ErbB-2 class receptor binding PubMed 
    enables ErbB-3 class receptor binding  
    enables chemorepellent activity  
    enables chemorepellent activity PubMed 
    enables growth factor activity  
    enables growth factor activity  
    enables integrin binding  
    enables protein binding PubMed 
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase activator activity  
    enables receptor ligand activity PubMed 
    enables receptor ligand activity PubMed 
    enables receptor ligand activity PubMed 
    enables receptor tyrosine kinase binding PubMed 
    enables signaling receptor binding  
    enables transcription coregulator activity PubMed 
    Items 1 - 25 of 91
    Process Evidence Code Pubs
    involved_in ERBB signaling pathway  
    involved_in ERBB2-ERBB3 signaling pathway  
    involved_in ERBB2-ERBB3 signaling pathway PubMed 
    involved_in ERBB2-ERBB3 signaling pathway PubMed 
    involved_in ERBB2-ERBB3 signaling pathway PubMed 
    involved_in ERBB2-ERBB4 signaling pathway PubMed 
    involved_in ERBB3 signaling pathway  
    involved_in ERBB4 signaling pathway  
    involved_in ERBB4 signaling pathway PubMed 
    involved_in ERBB4 signaling pathway PubMed 
    involved_in ERBB4-ERBB4 signaling pathway PubMed 
    acts_upstream_of_or_within MAPK cascade PubMed 
    involved_in Schwann cell development PubMed 
    acts_upstream_of_or_within Schwann cell differentiation PubMed 
    involved_in activation of protein kinase B activity  
    involved_in activation of transmembrane receptor protein tyrosine kinase activity  
    involved_in brain development  
    acts_upstream_of_or_within cardiac conduction system development PubMed 
    involved_in cardiac muscle cell differentiation PubMed 
    involved_in cardiac muscle cell myoblast differentiation  
    acts_upstream_of_or_within cardiac muscle tissue development PubMed 
    involved_in cell differentiation  
    acts_upstream_of_or_within cell morphogenesis PubMed 
    involved_in cell population proliferation  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex PubMed 
    acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain PubMed 
    involved_in endocardial cell differentiation  
    acts_upstream_of_or_within glial cell differentiation PubMed 
    acts_upstream_of_or_within glial cell fate commitment PubMed 
    acts_upstream_of_or_within heart development PubMed 
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in memory  
    acts_upstream_of_or_within muscle organ development PubMed 
    involved_in myelination PubMed 
    acts_upstream_of_or_within myelination in peripheral nervous system PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of corticosterone secretion  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within negative regulation of neuron migration PubMed 
    acts_upstream_of_or_within negative regulation of protein catabolic process PubMed 
    involved_in negative regulation of secretion  
    involved_in nervous system development  
    acts_upstream_of_or_within nervous system development PubMed 
    acts_upstream_of_or_within neuron fate commitment PubMed 
    acts_upstream_of_or_within neuron migration PubMed 
    acts_upstream_of_or_within oligodendrocyte differentiation PubMed 
    involved_in peripheral nervous system development  
    acts_upstream_of_or_within peripheral nervous system development PubMed 
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction PubMed 
    involved_in positive regulation of Schwann cell proliferation  
    involved_in positive regulation of axon regeneration  
    acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in positive regulation of cardiac muscle cell differentiation PubMed 
    involved_in positive regulation of cardiac muscle cell proliferation  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of membrane permeability  
    involved_in positive regulation of neural precursor cell proliferation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of peptidyl-tyrosine autophosphorylation  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of striated muscle cell differentiation PubMed 
    involved_in postsynapse to nucleus signaling pathway PubMed 
    involved_in postsynapse to nucleus signaling pathway PubMed 
    acts_upstream_of protein catabolic process PubMed 
    acts_upstream_of_or_within protein-containing complex disassembly  
    acts_upstream_of_or_within regulation of cell differentiation PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in regulation of presynapse assembly PubMed 
    involved_in regulation of presynapse assembly PubMed 
    acts_upstream_of_or_within sensory perception of pain PubMed 
    involved_in sequestering of metal ion  
    involved_in signal transduction  
    acts_upstream_of_or_within synapse assembly PubMed 
    involved_in synaptic membrane adhesion PubMed 
    involved_in synaptic membrane adhesion PubMed 
    involved_in synaptic membrane adhesion PubMed 
    involved_in ventricular cardiac muscle cell differentiation  
    involved_in ventricular trabecula myocardium morphogenesis  
    involved_in wound healing  
    Items 1 - 25 of 91
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in apical plasma membrane  
    located_in axon PubMed 
    located_in cytoplasm PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    is_active_in extracellular space PubMed 
    is_active_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in mossy fiber rosette PubMed 
    is_active_in mossy fiber rosette PubMed 
    is_active_in mossy fiber rosette PubMed 
    located_in neuromuscular junction PubMed 
    located_in neuron projection  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    is_active_in postsynaptic density membrane PubMed 
    is_active_in presynaptic active zone membrane PubMed 
    located_in synapse PubMed 
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    pro-neuregulin-1, membrane-bound isoform
    Names
    heregulin
    type I neuregulin 1
    type III neuregulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364421.2NP_001351350.1  pro-neuregulin-1, membrane-bound isoform isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407, AC136147
      Consensus CDS
      CCDS90385.1
      UniProtKB/Swiss-Prot
      Q6DR98
      UniProtKB/TrEMBL
      A0A140LJ88
      Related
      ENSMUSP00000146456.2, ENSMUST00000207470.3
      Conserved Domains (3) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:240633
      Neuregulin; Neuregulin family
    2. NM_001364422.1NP_001351351.1  pro-neuregulin-1, membrane-bound isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      Conserved Domains (1) summary
      pfam02158
      Location:287680
      Neuregulin; Neuregulin family
    3. NM_001364423.1NP_001351352.1  pro-neuregulin-1, membrane-bound isoform isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      Conserved Domains (2) summary
      pfam00008
      Location:245275
      EGF; EGF-like domain
      pfam02158
      Location:353708
      Neuregulin; Neuregulin family
    4. NM_001364424.1NP_001351353.1  pro-neuregulin-1, membrane-bound isoform isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      UniProtKB/TrEMBL
      Q3URY7
      Conserved Domains (1) summary
      pfam02158
      Location:295484
      Neuregulin; Neuregulin family
    5. NM_001364425.1NP_001351354.1  pro-neuregulin-1, membrane-bound isoform isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      Conserved Domains (1) summary
      pfam02158
      Location:75430
      Neuregulin; Neuregulin family
    6. NM_001364426.1NP_001351355.1  pro-neuregulin-1, membrane-bound isoform isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      Consensus CDS
      CCDS90383.1
      UniProtKB/TrEMBL
      A0A140LIG9, Q3URY7
      Related
      ENSMUSP00000146816.2, ENSMUST00000208497.3
      Conserved Domains (1) summary
      pfam02158
      Location:295483
      Neuregulin; Neuregulin family
    7. NM_001364427.1NP_001351356.1  pro-neuregulin-1, membrane-bound isoform isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      UniProtKB/TrEMBL
      Q3URY7
      Conserved Domains (1) summary
      pfam02158
      Location:321510
      Neuregulin; Neuregulin family
    8. NM_001364428.1NP_001351357.1  pro-neuregulin-1, membrane-bound isoform isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      UniProtKB/TrEMBL
      Q3URY7
      Conserved Domains (1) summary
      pfam02158
      Location:287476
      Neuregulin; Neuregulin family
    9. NM_001364429.1NP_001351358.1  pro-neuregulin-1, membrane-bound isoform isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407
      UniProtKB/TrEMBL
      Q3TD94
      Related
      ENSMUSP00000159071.2, ENSMUST00000207678.3
      Conserved Domains (2) summary
      pfam00008
      Location:78108
      EGF; EGF-like domain
      pfam02158
      Location:123311
      Neuregulin; Neuregulin family
    10. NM_001364430.1NP_001351359.1  pro-neuregulin-1, membrane-bound isoform isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC132407
    11. NM_001364431.1NP_001351360.1  pro-neuregulin-1, membrane-bound isoform isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC132407, AK048708
      Consensus CDS
      CCDS90382.1
      UniProtKB/TrEMBL
      A0A5F8MPT0, Q8BX76
      Related
      ENSMUSP00000159096.2, ENSMUST00000238812.2
      Conserved Domains (1) summary
      cl28647
      Location:236279
      PHA02887; EGF-like protein; Provisional
    12. NM_178591.3NP_848706.2  pro-neuregulin-1, membrane-bound isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127374, AC132407, AK141037, AY648975, BY238526
      Consensus CDS
      CCDS40315.1
      UniProtKB/TrEMBL
      Q6DR99
      Related
      ENSMUSP00000073546.5, ENSMUST00000073884.7
      Conserved Domains (2) summary
      PHA02887
      Location:236279
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:295688
      Neuregulin; Neuregulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      32299493..33381858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509068.5XP_006509131.1  pro-neuregulin-1, membrane-bound isoform isoform X10

      Conserved Domains (4) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:361450
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam00008
      Location:369399
      EGF; EGF-like domain
      pfam02158
      Location:443798
      Neuregulin; Neuregulin family
    2. XM_006509067.5XP_006509130.1  pro-neuregulin-1, membrane-bound isoform isoform X9

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:369399
      EGF; EGF-like domain
      pfam02158
      Location:451806
      Neuregulin; Neuregulin family
    3. XM_006509065.5XP_006509128.1  pro-neuregulin-1, membrane-bound isoform isoform X7

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:369399
      EGF; EGF-like domain
      pfam02158
      Location:477832
      Neuregulin; Neuregulin family
    4. XM_006509066.5XP_006509129.1  pro-neuregulin-1, membrane-bound isoform isoform X8

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:386416
      EGF; EGF-like domain
      pfam02158
      Location:468823
      Neuregulin; Neuregulin family
    5. XM_006509061.5XP_006509124.1  pro-neuregulin-1, membrane-bound isoform isoform X3

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:386416
      EGF; EGF-like domain
      pfam02158
      Location:494849
      Neuregulin; Neuregulin family
    6. XM_006509064.5XP_006509127.1  pro-neuregulin-1, membrane-bound isoform isoform X6

      Conserved Domains (4) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:395484
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam00008
      Location:403433
      EGF; EGF-like domain
      pfam02158
      Location:477832
      Neuregulin; Neuregulin family
    7. XM_006509062.5XP_006509125.1  pro-neuregulin-1, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      A0A140LHZ9
      Related
      ENSMUSP00000146617.3, ENSMUST00000209107.4
      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:403433
      EGF; EGF-like domain
      pfam02158
      Location:485840
      Neuregulin; Neuregulin family
    8. XM_006509060.5XP_006509123.1  pro-neuregulin-1, membrane-bound isoform isoform X2

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:403433
      EGF; EGF-like domain
      pfam02158
      Location:503858
      Neuregulin; Neuregulin family
    9. XM_006509059.5XP_006509122.1  pro-neuregulin-1, membrane-bound isoform isoform X1

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:403433
      EGF; EGF-like domain
      pfam02158
      Location:511866
      Neuregulin; Neuregulin family
    10. XM_006509063.5XP_006509126.1  pro-neuregulin-1, membrane-bound isoform isoform X5

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:403433
      EGF; EGF-like domain
      pfam02158
      Location:480835
      Neuregulin; Neuregulin family
    11. XM_030243394.1XP_030099254.1  pro-neuregulin-1, membrane-bound isoform isoform X18

      UniProtKB/TrEMBL
      A0A5F8MPJ0
      Conserved Domains (3) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:156186
      EGF; EGF-like domain
      pfam02158
      Location:264619
      Neuregulin; Neuregulin family
    12. XM_030243393.2XP_030099253.1  pro-neuregulin-1, membrane-bound isoform isoform X16

      UniProtKB/TrEMBL
      A0A140LJ88, A0A140LJC1
      Related
      ENSMUSP00000147156.2, ENSMUST00000208205.3
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182274
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:267622
      Neuregulin; Neuregulin family
    13. XM_006509078.5XP_006509141.1  pro-neuregulin-1, membrane-bound isoform isoform X15

      UniProtKB/TrEMBL
      A0A140LJ88
      Related
      ENSMUSP00000147121.2, ENSMUST00000208488.2
      Conserved Domains (3) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:298653
      Neuregulin; Neuregulin family
    14. XM_036153857.1XP_036009750.1  pro-neuregulin-1, membrane-bound isoform isoform X17

      UniProtKB/TrEMBL
      A0A140LIP8, A0A140LJ88
      Related
      ENSMUSP00000146905.2, ENSMUST00000207417.3
      Conserved Domains (4) summary
      PHA03099
      Location:182271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:264619
      Neuregulin; Neuregulin family
      cd05895
      Location:37129
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    15. XM_006509072.4XP_006509135.1  pro-neuregulin-1, membrane-bound isoform isoform X12

      UniProtKB/TrEMBL
      A0A5F8MPT8
      Related
      ENSMUSP00000159112.2, ENSMUST00000238842.2
      Conserved Domains (2) summary
      pfam00008
      Location:245275
      EGF; EGF-like domain
      pfam02158
      Location:322677
      Neuregulin; Neuregulin family
    16. XM_036153856.1XP_036009749.1  pro-neuregulin-1, membrane-bound isoform isoform X11

      Conserved Domains (2) summary
      pfam00008
      Location:245275
      EGF; EGF-like domain
      pfam02158
      Location:353708
      Neuregulin; Neuregulin family
    17. XM_036153858.1XP_036009751.1  pro-neuregulin-1, membrane-bound isoform isoform X23

      Conserved Domains (1) summary
      pfam02158
      Location:9364
      Neuregulin; Neuregulin family
    18. XM_036153859.1XP_036009752.1  pro-neuregulin-1, membrane-bound isoform isoform X23

      Conserved Domains (1) summary
      pfam02158
      Location:9364
      Neuregulin; Neuregulin family
    19. XM_017312640.3XP_017168129.1  pro-neuregulin-1, membrane-bound isoform isoform X20

      Conserved Domains (1) summary
      pfam02158
      Location:75430
      Neuregulin; Neuregulin family
    20. XM_036153860.1XP_036009753.1  pro-neuregulin-1, membrane-bound isoform isoform X23

      Conserved Domains (1) summary
      pfam02158
      Location:9364
      Neuregulin; Neuregulin family
    21. XM_017312641.1XP_017168130.1  pro-neuregulin-1, membrane-bound isoform isoform X22

      Conserved Domains (1) summary
      pfam02158
      Location:39394
      Neuregulin; Neuregulin family
    22. XM_011242133.1XP_011240435.1  pro-neuregulin-1, membrane-bound isoform isoform X21

      Conserved Domains (1) summary
      pfam02158
      Location:73428
      Neuregulin; Neuregulin family
    23. XM_006509077.5XP_006509140.1  pro-neuregulin-1, membrane-bound isoform isoform X14

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:395484
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam02158
      Location:477634
      Neuregulin; Neuregulin family
    24. XM_006509076.5XP_006509139.1  pro-neuregulin-1, membrane-bound isoform isoform X13

      Conserved Domains (3) summary
      cd05895
      Location:266340
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:403433
      EGF; EGF-like domain
      pfam02158
      Location:480637
      Neuregulin; Neuregulin family
    25. XM_006509081.4XP_006509144.1  pro-neuregulin-1, membrane-bound isoform isoform X19

      UniProtKB/TrEMBL
      Q3URY7
      Conserved Domains (2) summary
      PHA02887
      Location:236278
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:322479
      Neuregulin; Neuregulin family
    External link. Please review our privacy policy.