U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pigx phosphatidylinositol glycan anchor biosynthesis, class X [ Mus musculus (house mouse) ]

    Gene ID: 72084, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pigxprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Xprovided by MGI
    Primary source
    MGI:MGI:1919334
    See related
    Ensembl:ENSMUSG00000023791 AllianceGenome:MGI:1919334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG-X; 2010319C14Rik
    Summary
    This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 20.4), placenta adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pigx in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31903234..31918545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32084416..32099727, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 5 Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_40638 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E7439 Neighboring gene predicted gene, 26419 Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene STARR-positive B cell enhancer ABC_E4165 Neighboring gene centrosomal protein 19 Neighboring gene STARR-seq mESC enhancer starr_40643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32130316-32130510 Neighboring gene STARR-positive B cell enhancer ABC_E7441 Neighboring gene negative regulator of reactive oxygen species

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulatory network analysis of hypertension and hypotension microarray data from mouse model. Zhu Y, et al. Clin Exp Hypertens, 2018. PMID 29400567
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, et al. Mol Biol Cell, 2005 Mar. PMID 15635094, Free PMC Article
    4. Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival. Lukacs M, et al. Elife, 2019 Jun 24. PMID 31232685, Free PMC Article
    5. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, et al. Mol Psychiatry, 2021 Mar. PMID 30976085, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sept6 and Pigx might participate in the pathogenesis of high blood pressure.
      Title: Regulatory network analysis of hypertension and hypotension microarray data from mouse model.
    2. A non-AUG translation initiation site (CUG) is used in rat Pigx
      Title: Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol-glycan biosynthesis class X protein
    Names
    phosphatidylinositol glycan, class X

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111025.1 → NP_001104495.1  phosphatidylinositol-glycan biosynthesis class X protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      BX525135, BY708475, CF581933
      Consensus CDS
      CCDS49824.1
      UniProtKB/TrEMBL
      A0A087WSN5, F6YX19
      Related
      ENSMUSP00000141122.3, ENSMUST00000189013.8
      Conserved Domains (1) summary
      pfam08320
      Location:48 → 244
      PIG-X; PIG-X / PBN1

    2. NM_024464.3 → NP_077784.2  phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_077784.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008583, BY708475, CF581933
      Consensus CDS
      CCDS28113.2
      UniProtKB/Swiss-Prot
      Q99LV7
      UniProtKB/TrEMBL
      F7DFD7
      Related
      ENSMUSP00000093819.5, ENSMUST00000096109.11
      Conserved Domains (1) summary
      pfam08320
      Location:50 → 246
      PIG-X; PIG-X / PBN1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31903234..31918545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LV7.2 GenPept UniProtKB/Swiss-Prot:Q99LV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous