Bspry B-box and SPRY domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bspryprovided by MGI
Official Full Name: B-box and SPRY domain containingprovided by MGI
Primary source: MGI:MGI:2177191
See related: Ensembl:ENSMUSG00000028392 AllianceGenome:MGI:2177191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cell leading edge and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including cornea epithelium; genitourinary system; gut; nose; and salivary gland primordium. Orthologous to human BSPRY (B-box and SPRY domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 181.8), colon adult (RPKM 118.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.16 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (62398248..62415537)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (62480011..62497300)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the treatment of Leydig cell dysfunction-related diseases.
Title: CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the treatment of Leydig cell dysfunction-related diseases.
associated with both embryonic stem cell pluripotency and early embryonic development
Title: B-box and SPRY domain containing protein (BSPRY) is associated with the maintenance of mouse embryonic stem cell pluripotency and early embryonic development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin D binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B box and SPRY domain-containing protein

Names: zetin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368623.1 → NP_001355552.1 B box and SPRY domain-containing protein isoform 2

Status: VALIDATED

Source sequence(s)

AL732594

Consensus CDS

CCDS89757.1

UniProtKB/Swiss-Prot

Q3TU74, Q80YW5, Q8BZF0, Q99KV7, Q9ER70

Related

ENSMUSP00000103073.4, ENSMUST00000107449.4

Conserved Domains (1) summary

cl02614
Location:282 → 449

SPRY; SPRY domain
NM_001429886.1 → NP_001416815.1 B box and SPRY domain-containing protein isoform 3

Status: VALIDATED

Source sequence(s)

AL732594
NM_138653.2 → NP_619594.1 B box and SPRY domain-containing protein isoform 1

See identical proteins and their annotated locations for NP_619594.1

Status: VALIDATED

Source sequence(s)

AL732594

Consensus CDS

CCDS18241.1

UniProtKB/TrEMBL

B2RT02

Related

ENSMUSP00000030088.6, ENSMUST00000030088.12

Conserved Domains (1) summary

cl02614
Location:282 → 449

SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

62398248..62415537

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537676.4 → XP_006537739.2 B box and SPRY domain-containing protein isoform X1

Conserved Domains (1) summary

cl00034
Location:69 → 111

Bbox_SF; B-box-type zinc finger superfamily