Matr3 matrin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Matr3provided by MGI
Official Full Name: matrin 3provided by MGI
Primary source: MGI:MGI:1298379
See related: Ensembl:ENSMUSG00000037236 AllianceGenome:MGI:1298379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0723; 1110061A14Rik; 2810017I02Rik; D030046F20Rik
Summary: Predicted to enable identical protein binding activity and miRNA binding activity. Acts upstream of or within blastocyst formation; heart valve development; and ventricular septum development. Located in nucleus. Is expressed in several structures, including blood vessel layer; branchial arch; heart; lung; and telencephalon. Used to study amyotrophic lateral sclerosis type 21. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 21. Orthologous to human MATR3 (matrin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 68.8), CNS E18 (RPKM 62.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.14 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35686462..35724526)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35562158..35592045)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.
Title: Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.
MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
Title: MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.
Title: Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.
MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
Title: MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
Title: Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
proteomic approach revealed that Matrin-3 phosphorylation was essential for FGF2-dependent maintenance of NSCs in vitro and in vivo.
Title: Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.
Matrin 3 (MATR3) is a novel protein interactor of PABPN1. MATR3 together with PABPN1 is required for normal paraspeckle function.
Title: Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.
Matrin 3 declines significantly in the central nervous system through early development and young adulthood before stabilizing.
Title: Heterogeneity of Matrin 3 in the developing and aging murine central nervous system.
Matr3(Gt-ex13) gene trap insertion disturb the polyadenylation of MATR3 transcripts and alter Matrin 3 protein expression.
Title: MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
Matrin 3 interacts specifically with the heat shock proteins glucose-regulated protein 78, GRP75 and glutathione S-transferase pi isoform 2.
Title: Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI841759 (e-PCR)
- UniSTS:181089

NoName (e-PCR)
- UniSTS:237776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart valve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: matrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399983.1 → NP_001386912.1 matrin-3 isoform a

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q5BL18
NM_001399984.1 → NP_001386913.1 matrin-3 isoform a

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q5BL18

Related

ENSMUSP00000158074.2, ENSMUST00000235199.2
NM_001399985.1 → NP_001386914.1 matrin-3 isoform a

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q5BL18
NM_001399986.1 → NP_001386915.1 matrin-3 isoform a

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q5BL18
NM_001399988.1 → NP_001386917.1 matrin-3 isoform b

Status: VALIDATED

Source sequence(s)

AC121821
NM_001399989.1 → NP_001386918.1 matrin-3 isoform c

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/TrEMBL

A0A494BAD4

Related

ENSMUSP00000158036.2, ENSMUST00000237365.2
NM_001399990.1 → NP_001386919.1 matrin-3 isoform d

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/TrEMBL

A0A494BAZ7

Related

ENSMUSP00000157641.2, ENSMUST00000237061.2
NM_001399991.1 → NP_001386920.1 matrin-3 isoform d

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/TrEMBL

A0A494BAZ7

Related

ENSMUSP00000158418.2, ENSMUST00000235960.2
NM_001399992.1 → NP_001386921.1 matrin-3 isoform d

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/TrEMBL

A0A494BAZ7

Related

ENSMUSP00000158302.2, ENSMUST00000236507.2
NM_001399993.1 → NP_001386922.1 matrin-3 isoform d

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/TrEMBL

A0A494BAZ7
NM_001414500.1 → NP_001401429.1 matrin-3 isoform a

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q5BL18
NM_001414501.1 → NP_001401430.1 matrin-3 isoform a

Status: VALIDATED

Source sequence(s)

AC121821

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q5BL18
NM_001414502.1 → NP_001401431.1 matrin-3 isoform e

Status: VALIDATED

Source sequence(s)

AC121821
NM_010771.7 → NP_034901.2 matrin-3 isoform a

See identical proteins and their annotated locations for NP_034901.2

Status: VALIDATED

Source sequence(s)

AC121821

Consensus CDS

CCDS29142.1

UniProtKB/Swiss-Prot

Q8K310

UniProtKB/TrEMBL

Q3TTX0, Q4FJT0, Q5BL18

Related

ENSMUSP00000125761.2, ENSMUST00000166793.10

Conserved Domains (4) summary

smart00451
Location:797 → 832

ZnF_U1; U1-like zinc finger

COG5271
Location:567 → 777

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd12714
Location:398 → 473

RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3

cd12715
Location:496 → 575

RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3