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    St6galnac3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 20447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St6galnac3provided by MGI
    Official Full Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3provided by MGI
    Primary source
    MGI:MGI:1341828
    See related
    Ensembl:ENSMUSG00000052544 AllianceGenome:MGI:1341828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat7c
    Summary
    Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ceramide metabolic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Predicted to be located in nucleoplasm. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; intestine; and nervous system. Orthologous to human ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 1.3), placenta adult (RPKM 1.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St6galnac3 in Genome Data Viewer
    Location:
    3 H3; 3 77.82 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152903911..153430804, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153198274..153725133, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930482G09 gene Neighboring gene RIKEN cDNA 1700094M23 gene Neighboring gene STARR-seq mESC enhancer starr_09301 Neighboring gene STARR-positive B cell enhancer mm9_chr3:152853033-152853333 Neighboring gene predicted gene, 54205 Neighboring gene STARR-seq mESC enhancer starr_09302 Neighboring gene STARR-seq mESC enhancer starr_09303 Neighboring gene STARR-seq mESC enhancer starr_09304 Neighboring gene predicted gene, 33066 Neighboring gene RIKEN cDNA 1700012D16 gene Neighboring gene predicted gene, 54206 Neighboring gene predicted gene, 52634 Neighboring gene STARR-seq mESC enhancer starr_09307 Neighboring gene STARR-seq mESC enhancer starr_09311 Neighboring gene STARR-seq mESC enhancer starr_09312 Neighboring gene STARR-seq mESC enhancer starr_09315 Neighboring gene STARR-seq mESC enhancer starr_09316 Neighboring gene predicted gene, 32721 Neighboring gene predicted gene, 52633 Neighboring gene STARR-seq mESC enhancer starr_09321 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene Neighboring gene predicted gene, 22206 Neighboring gene RIKEN cDNA 5730460C07 gene Neighboring gene predicted gene, 25757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Fuseya S, et al. Sci Rep, 2023 Jun 29. PMID 37386100, Free PMC Article
    2. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. Lee YC, et al. J Biol Chem, 1999 Apr 23. PMID 10207017
    3. Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR. Takashima S, et al. Biochem Biophys Res Commun, 1999 Jun 24. PMID 10381338
    4. Constraint and divergence of global gene expression in the mammalian embryo. Spies N, et al. Elife, 2015 Apr 14. PMID 25871848, Free PMC Article
    5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
      Title: Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosylceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Names
    SIAT7-C
    ST6GalNAc III
    ST6GalNAcIII
    STY
    galNAc alpha-2,6-sialyltransferase III
    sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
    sialyltransferase 7C
    NP_001404549.1
    NP_001404550.1
    NP_035502.1
    XP_006501282.1
    XP_006501283.1
    XP_006501284.1
    XP_006501285.1
    XP_011238356.1
    XP_030108370.1
    XP_030108372.1
    XP_036018881.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417620.1 → NP_001404549.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC103637, AC121914, AC122052, AC133943, AC163209

    2. NM_001417621.1 → NP_001404550.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121914, AC133943, AC163209

    3. NM_011372.3 → NP_035502.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1

      See identical proteins and their annotated locations for NP_035502.1

      Status: VALIDATED

      Source sequence(s)
      AC103637, AC121914, AC133943, AC163209
      Consensus CDS
      CCDS38677.1
      UniProtKB/Swiss-Prot
      Q9JHP5, Q9WUV2
      UniProtKB/TrEMBL
      Q544M3
      Related
      ENSMUSP00000143747.2, ENSMUST00000200397.5
      Conserved Domains (1) summary
      pfam00777
      Location:77 → 297
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_184541.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC103637, AC121914, AC133943, AC163209

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      152903911..153430804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252510.1 → XP_030108370.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4

      Conserved Domains (1) summary
      pfam00777
      Location:53 → 273
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006501220.5 → XP_006501283.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:72 → 292
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006501221.5 → XP_006501284.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:87 → 149
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_006501219.5 → XP_006501282.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:87 → 307
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_030252512.1 → XP_030108372.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X8

      Conserved Domains (1) summary
      pfam00777
      Location:7 → 209
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_036162988.1 → XP_036018881.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X8

      Conserved Domains (1) summary
      pfam00777
      Location:7 → 209
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_011240054.4 → XP_011238356.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X7

      Conserved Domains (1) summary
      pfam00777
      Location:87 → 149
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. XM_006501222.5 → XP_006501285.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:87 → 149
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. XR_003954302.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUV2.2 GenPept UniProtKB/Swiss-Prot:Q9WUV2

    Gene LinkOut

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