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    Dus4l dihydrouridine synthase 4 like [ Mus musculus (house mouse) ]

    Gene ID: 71916, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Dus4lprovided by MGI
    Official Full Name
    dihydrouridine synthase 4 likeprovided by MGI
    Primary source
    MGI:MGI:1919166
    See related
    Ensembl:ENSMUSG00000020648 AllianceGenome:MGI:1919166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp35; 2310069P03Rik; 2700089B10Rik
    Summary
    Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.9), limb E14.5 (RPKM 2.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dus4l in Genome Data Viewer
    Location:
    12 A3; 12 13.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31690049..31704834, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31640050..31654866, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 26, member 4 Neighboring gene B cell receptor associated protein 29 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32339618-32339801 Neighboring gene STARR-seq mESC enhancer starr_31859 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene STARR-seq mESC enhancer starr_31862 Neighboring gene G protein-coupled receptor 22 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130363

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-dihydrouridine20a synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine20b synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA dihydrouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA dihydrouridine synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
    NP_001404957.1
    NP_082278.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418028.1 → NP_001404957.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119950

    2. NM_028002.3 → NP_082278.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119950
      Consensus CDS
      CCDS25865.1
      UniProtKB/Swiss-Prot
      Q32M08, Q9D6P4
      UniProtKB/TrEMBL
      A0A0R4J016
      Related
      ENSMUSP00000020977.3, ENSMUST00000020977.4
      Conserved Domains (2) summary
      COG0042
      Location:32 → 311
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd02801
      Location:28 → 257
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    RNA

    1. NR_184675.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119950

    2. NR_184676.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119950

    3. NR_184677.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119950

    4. NR_184678.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119950

    5. NR_184679.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119950

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      31690049..31704834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32M08.1 GenPept UniProtKB/Swiss-Prot:Q32M08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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