MT1M metallothionein 1M [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT1Mprovided by HGNC
Official Full Name: metallothionein 1Mprovided by HGNC
Primary source: HGNC:HGNC:14296
See related: Ensembl:ENSG00000205364 MIM:156357; AllianceGenome:HGNC:14296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT1; MT1K; MT-1M; MT-IM
Summary: This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
Expression: Broad expression in colon (RPKM 54.9), small intestine (RPKM 40.3) and 14 other tissues See more
Orthologs: all
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56632659..56633981)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62427638..62428960)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56666571..56667893)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MT1M regulates gastric cancer progression and stemness by modulating the Hedgehog pathway protein GLI1.
Title: MT1M regulates gastric cancer progression and stemness by modulating the Hedgehog pathway protein GLI1.
Metallothionein MT1M Suppresses Carcinogenesis of Esophageal Carcinoma Cells through Inhibition of the Epithelial-Mesenchymal Transition and the SOD1/PI3K Axis.
Title: Metallothionein MT1M Suppresses Carcinogenesis of Esophageal Carcinoma Cells through Inhibition of the Epithelial-Mesenchymal Transition and the SOD1/PI3K Axis.
MT1M can suppress hepatocellular carcinoma cell proliferation and induce apoptosis through downregulating Bcl-2, upregulating Bax, and enhancing Caspase-3 activity.
Title: The effect and mechanism of metallothionein MT1M on hepatocellular carcinoma cell.
In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression
Title: DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
MiR-545-3p, which served as a tumor promoter, post-transcriptionally regulate MT1M in HCC through binding to its untranslated region (3'UTR).
Title: MiR-545-3p/MT1M axis regulates cell proliferation, invasion and migration in hepatocellular carcinoma.
Results found that MT1M is downregulated in hepatocellular carcinoma (HCC) tumors, and it suppressed HCC tumorigenesis possibly by inducing cell cycle arrest, enhancing apoptosis and inhibiting cell migration and invasion. These findings provide evidence that MT1M might be a tumor suppressor in HCC tumorigenesis.
Title: Metallothionein 1M suppresses tumorigenesis in hepatocellular carcinoma.
Low MT1M expression is associated with poor hepatocellular carcinoma prognosis following curative resection.
Title: Low metallothionein 1M expression association with poor hepatocellular carcinoma prognosis after curative resection.
miR-24-3p plays an important role in the initiation and progression of hepatocellular carcinoma by targeting metallothionein 1M.
Title: MiR-24-3p enhances cell growth in hepatocellular carcinoma by targeting metallothionein 1M.
MT1M and MT1G promoter methylation may be used as serum biomarkers for noninvasive detection of hepatocellular carcinoma.
Title: MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma.
Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas.
Title: Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S3071 (e-PCR)
- UniSTS:13890

NoName (e-PCR)
- UniSTS:484175

D16S2938 (e-PCR)
- UniSTS:153822

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metallothionein-1M

Names: metallothionein 1K; metallothionein 1Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030326.2 RefSeqGene

Range

5002..6324

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176870.3 → NP_789846.2 metallothionein-1M

Status: REVIEWED

Source sequence(s)

AC026461

Consensus CDS

CCDS42166.1

UniProtKB/Swiss-Prot

Q8N339, Q8TDN3, Q93083

Related

ENSP00000369146.3, ENST00000379818.4

Conserved Domains (1) summary

pfam00131
Location:1 → 61

Metallothio; Metallothionein