NTRK3 neurotrophic receptor tyrosine kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTRK3provided by HGNC
Official Full Name: neurotrophic receptor tyrosine kinase 3provided by HGNC
Primary source: HGNC:HGNC:8033
See related: Ensembl:ENSG00000140538 MIM:191316; AllianceGenome:HGNC:8033
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRKC; GP145-TrkC; gp145(trkC)
Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression: Biased expression in brain (RPKM 2.8), fat (RPKM 1.2) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q25.3

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (87859751..88256739, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (85614323..86011407, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (88402982..88799970, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.
Title: NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.
Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
Title: Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
Title: Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology.
Title: High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology.
TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
Title: TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile.
Title: Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile.
Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
Title: Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.
Title: An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.
[Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].
Title: [Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].
Fluorescent In Situ Hybridization Must be Preferred to pan-TRK Immunohistochemistry to Diagnose NTRK3-rearranged Gastrointestinal Stromal Tumors (GIST).
Title: Fluorescent In Situ Hybridization Must be Preferred to pan-TRK Immunohistochemistry to Diagnose NTRK3-rearranged Gastrointestinal Stromal Tumors (GIST).

Submit: New GeneRIF Correction See all GeneRIFs (130)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15S550 (e-PCR)
- UniSTS:20764

D18S99 (e-PCR)
- UniSTS:147758

D15S99 (e-PCR)
- UniSTS:147016

SHGC-144703 (e-PCR)
- UniSTS:172368

SHGC-89268 (e-PCR)
- UniSTS:170585

BE106688 (e-PCR)
- UniSTS:246364

D15S930 (e-PCR)
- UniSTS:63346

SHGC-154732 (e-PCR)
- UniSTS:182900

RH122735 (e-PCR)
- UniSTS:134006

SHGC-30089 (e-PCR)
- UniSTS:81281

SHGC-156073 (e-PCR)
- UniSTS:182918

RH122586 (e-PCR)
- UniSTS:138649

RH122647 (e-PCR)
- UniSTS:135092

D15S1230 (e-PCR)
- UniSTS:58036

RH78103 (e-PCR)
- UniSTS:454

PMC311040P17 (e-PCR)
- UniSTS:272854

RH102137 (e-PCR)
- UniSTS:96471

PMC311040P20 (e-PCR)
- UniSTS:272858

PMC311040P21 (e-PCR)
- UniSTS:272859

RH119005 (e-PCR)
- UniSTS:138973

PMC311040P6 (e-PCR)
- UniSTS:272863

PMC311040P8 (e-PCR)
- UniSTS:272865

D15S171 (e-PCR)
- UniSTS:148199

SHGC-112537 (e-PCR)
- UniSTS:168686

SGC30075 (e-PCR)
- UniSTS:81653

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activation of protein kinase B activity	IDA Inferred from Direct Assay more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NT-3 growth factor receptor

Names: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; neurotrophic tyrosine kinase, receptor, type 3; tyrosine kinase receptor C

NP_001007157.1

EC 2.7.10.1

NP_001012338.1

EC 2.7.10.1

NP_001230030.1

EC 2.7.10.1

NP_001307063.1

EC 2.7.10.1

NP_001307064.1

EC 2.7.10.1

NP_001362739.1

EC 2.7.10.1

NP_001362740.1

EC 2.7.10.1

NP_001362741.1

EC 2.7.10.1

NP_001362742.1

EC 2.7.10.1

NP_001362743.1

EC 2.7.10.1

NP_002521.2

EC 2.7.10.1

XP_006720608.1

EC 2.7.10.1

XP_006720611.1

EC 2.7.10.1

XP_006720612.1

EC 2.7.10.1

XP_006720613.1

EC 2.7.10.1

XP_011519940.1

EC 2.7.10.1

XP_016877729.1

EC 2.7.10.1

XP_016877730.1

EC 2.7.10.1

XP_016877731.1

EC 2.7.10.1

XP_016877732.1

EC 2.7.10.1

XP_016877733.1

EC 2.7.10.1

XP_016877734.1

EC 2.7.10.1

XP_016877739.1

EC 2.7.10.1

XP_016877740.1

EC 2.7.10.1

XP_016877741.1

EC 2.7.10.1

XP_016877743.1

EC 2.7.10.1

XP_024305702.1

EC 2.7.10.1

XP_024305703.1

EC 2.7.10.1

XP_047288558.1

EC 2.7.10.1

XP_047288559.1

EC 2.7.10.1

XP_047288560.1

EC 2.7.10.1

XP_054234029.1

EC 2.7.10.1

XP_054234030.1

EC 2.7.10.1

XP_054234031.1

EC 2.7.10.1

XP_054234032.1

EC 2.7.10.1

XP_054234033.1

EC 2.7.10.1

XP_054234034.1

EC 2.7.10.1

XP_054234035.1

EC 2.7.10.1

XP_054234036.1

EC 2.7.10.1

XP_054234037.1

EC 2.7.10.1

XP_054234038.1

EC 2.7.10.1

XP_054234039.1

EC 2.7.10.1

XP_054234040.1

EC 2.7.10.1

XP_054234041.1

EC 2.7.10.1

XP_054234042.1

EC 2.7.10.1

XP_054234043.1

EC 2.7.10.1

XP_054234044.1

EC 2.7.10.1

XP_054234045.1

EC 2.7.10.1

XP_054234046.1

EC 2.7.10.1

XP_054234047.1

EC 2.7.10.1

XP_054234048.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029619.2 RefSeqGene

Range

5000..401988

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001007156.3 → NP_001007157.1 NT-3 growth factor receptor isoform c precursor

See identical proteins and their annotated locations for NP_001007157.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC009711, AC021677

Consensus CDS

CCDS32323.1

UniProtKB/TrEMBL

Q96CY4, X5DP84

Related

ENSP00000318328.3, ENST00000317501.9

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001012338.3 → NP_001012338.1 NT-3 growth factor receptor isoform a precursor

See identical proteins and their annotated locations for NP_001012338.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS32322.1

UniProtKB/Swiss-Prot

B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16288, Q16289

UniProtKB/TrEMBL

H0YM90, X5D2R1

Related

ENSP00000485864.1, ENST00000629765.3

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:532 → 832

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001243101.2 → NP_001230030.1 NT-3 growth factor receptor isoform d precursor

See identical proteins and their annotated locations for NP_001230030.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but lacks two alternate internal segments compared to isoform a.

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS58399.1

UniProtKB/TrEMBL

H0YM90, X5DNW6

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:524 → 810

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001320134.1 → NP_001307063.1 NT-3 growth factor receptor isoform e precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC021677, AF058390, AK309695, BM675026, S76476

UniProtKB/TrEMBL

X5DP84

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001320135.2 → NP_001307064.1 NT-3 growth factor receptor isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences in the coding and non-coding regions, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform f) has a shorter N-terminus and a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS81916.1

UniProtKB/TrEMBL

B7Z7U4, H0YM90

Related

ENSP00000437773.2, ENST00000542733.6

Conserved Domains (7) summary

cd04971
Location:221 → 298

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:113 → 203

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00410
Location:120 → 203

IG_like; Immunoglobulin like

sd00031
Location:7 → 30

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:5 → 62

LRR_8; Leucine rich repeat

pfam16920
Location:65 → 110

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl21453
Location:434 → 614

PKc_like; Protein Kinases, catalytic domain
NM_001375810.1 → NP_001362739.1 NT-3 growth factor receptor isoform a precursor

Status: REVIEWED

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS32322.1

UniProtKB/Swiss-Prot

B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16288, Q16289

UniProtKB/TrEMBL

H0YM90, X5D2R1

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:532 → 832

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001375811.1 → NP_001362740.1 NT-3 growth factor receptor isoform b precursor

Status: REVIEWED

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS10340.1

UniProtKB/TrEMBL

H0YM90, X5D7M5

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:532 → 818

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001375812.1 → NP_001362741.1 NT-3 growth factor receptor isoform d precursor

Status: REVIEWED

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS58399.1

UniProtKB/TrEMBL

H0YM90, X5DNW6

Related

ENSP00000453959.1, ENST00000557856.5

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:524 → 810

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001375813.1 → NP_001362742.1 NT-3 growth factor receptor isoform c precursor

Status: REVIEWED

Source sequence(s)

AC009711, AC021677

Consensus CDS

CCDS32323.1

UniProtKB/TrEMBL

Q96CY4, X5DP84

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001375814.1 → NP_001362743.1 NT-3 growth factor receptor isoform g precursor

Status: REVIEWED

Source sequence(s)

AC009711, AC021677

UniProtKB/TrEMBL

X5DP84

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_002530.4 → NP_002521.2 NT-3 growth factor receptor isoform b precursor

See identical proteins and their annotated locations for NP_002521.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.

Source sequence(s)

AC009711, AC011966, AC021677

Consensus CDS

CCDS10340.1

UniProtKB/TrEMBL

H0YM90, X5D7M5

Related

ENSP00000377990.1, ENST00000394480.6

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:532 → 818

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

87859751..88256739 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017022240.2 → XP_016877729.1 NT-3 growth factor receptor isoform X1

UniProtKB/TrEMBL

H0YM90, X5D7M5

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05094
Location:532 → 818

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_017022254.3 → XP_016877743.1 NT-3 growth factor receptor isoform X18

UniProtKB/TrEMBL

H0YM90

Conserved Domains (8) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00219
Location:538 → 835

TyrKc; Tyrosine kinase, catalytic domain

smart00410
Location:218 → 301

IG_like; Immunoglobulin like

cd05094
Location:532 → 843

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_017022244.3 → XP_016877733.1 NT-3 growth factor receptor isoform X4

UniProtKB/TrEMBL

H0YM90
XM_017022245.3 → XP_016877734.1 NT-3 growth factor receptor isoform X4

UniProtKB/TrEMBL

H0YM90
XM_017022243.2 → XP_016877732.1 NT-3 growth factor receptor isoform X4

UniProtKB/TrEMBL

H0YM90
XM_017022241.2 → XP_016877730.1 NT-3 growth factor receptor isoform X2

UniProtKB/TrEMBL

H0YM90
XM_017022252.3 → XP_016877741.1 NT-3 growth factor receptor isoform X17
XM_017022251.3 → XP_016877740.1 NT-3 growth factor receptor isoform X16
XM_006720545.5 → XP_006720608.1 NT-3 growth factor receptor isoform X5

UniProtKB/TrEMBL

H0YM90

Related

ENSP00000453511.1, ENST00000558676.5

Conserved Domains (7) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00410
Location:218 → 301

IG_like; Immunoglobulin like

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl21453
Location:532 → 712

PKc_like; Protein Kinases, catalytic domain
XM_017022242.3 → XP_016877731.1 NT-3 growth factor receptor isoform X3

UniProtKB/TrEMBL

H0YM90
XM_047432603.1 → XP_047288559.1 NT-3 growth factor receptor isoform X8
XM_047432602.1 → XP_047288558.1 NT-3 growth factor receptor isoform X7

Related

ENSP00000511943.1, ENST00000695463.1
XM_024449934.2 → XP_024305702.1 NT-3 growth factor receptor isoform X6

UniProtKB/TrEMBL

Q96CY4, X5DP84

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_024449935.2 → XP_024305703.1 NT-3 growth factor receptor isoform X9

UniProtKB/TrEMBL

X5DP84

Conserved Domains (5) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006720548.5 → XP_006720611.1 NT-3 growth factor receptor isoform X10

UniProtKB/TrEMBL

X5DP84

Conserved Domains (7) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:218 → 301

IG_like; Immunoglobulin like

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006720550.5 → XP_006720613.1 NT-3 growth factor receptor isoform X12

UniProtKB/TrEMBL

X5DP84

Conserved Domains (7) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:218 → 301

IG_like; Immunoglobulin like

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006720549.5 → XP_006720612.1 NT-3 growth factor receptor isoform X11

UniProtKB/TrEMBL

X5DP84

Conserved Domains (7) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:218 → 301

IG_like; Immunoglobulin like

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_011521638.4 → XP_011519940.1 NT-3 growth factor receptor isoform X14

UniProtKB/TrEMBL

X5DP84

Conserved Domains (7) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:218 → 301

IG_like; Immunoglobulin like

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_047432604.1 → XP_047288560.1 NT-3 growth factor receptor isoform X15
XM_017022250.3 → XP_016877739.1 NT-3 growth factor receptor isoform X13

UniProtKB/TrEMBL

X5DP84

RNA

XR_001751292.3 RNA Sequence
XR_002957645.2 RNA Sequence
XR_001751293.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

85614323..86011407 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054378054.1 → XP_054234029.1 NT-3 growth factor receptor isoform X1

UniProtKB/TrEMBL

X5D7M5
XM_054378073.1 → XP_054234048.1 NT-3 growth factor receptor isoform X18
XM_054378057.1 → XP_054234032.1 NT-3 growth factor receptor isoform X4
XM_054378059.1 → XP_054234034.1 NT-3 growth factor receptor isoform X4
XM_054378058.1 → XP_054234033.1 NT-3 growth factor receptor isoform X4
XM_054378055.1 → XP_054234030.1 NT-3 growth factor receptor isoform X2
XM_054378072.1 → XP_054234047.1 NT-3 growth factor receptor isoform X17
XM_054378071.1 → XP_054234046.1 NT-3 growth factor receptor isoform X16
XM_054378060.1 → XP_054234035.1 NT-3 growth factor receptor isoform X5
XM_054378056.1 → XP_054234031.1 NT-3 growth factor receptor isoform X3
XM_054378063.1 → XP_054234038.1 NT-3 growth factor receptor isoform X8
XM_054378062.1 → XP_054234037.1 NT-3 growth factor receptor isoform X7
XM_054378061.1 → XP_054234036.1 NT-3 growth factor receptor isoform X6

UniProtKB/TrEMBL

Q96CY4
XM_054378064.1 → XP_054234039.1 NT-3 growth factor receptor isoform X9
XM_054378065.1 → XP_054234040.1 NT-3 growth factor receptor isoform X10
XM_054378067.1 → XP_054234042.1 NT-3 growth factor receptor isoform X12
XM_054378066.1 → XP_054234041.1 NT-3 growth factor receptor isoform X11
XM_054378069.1 → XP_054234044.1 NT-3 growth factor receptor isoform X14
XM_054378070.1 → XP_054234045.1 NT-3 growth factor receptor isoform X15
XM_054378068.1 → XP_054234043.1 NT-3 growth factor receptor isoform X13