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Envelope surface glycoprotein gp120
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env
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The interaction of cell-associated HIV-1 gp120 with CXCR4-expressing target cells triggers apoptotic processes by activating caspase-9 and -3 |
PubMed
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env
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Treatment of human retinal capillary endothelial cells (HRCECs) with HIV-1 gp120 increases the numbers of apoptotic cells and expression of cleaved caspase-9 protein, but decreases mitochondrial membrane potential |
PubMed
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env
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Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 |
PubMed
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env
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Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 |
PubMed
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Envelope transmembrane glycoprotein gp41
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env
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Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 |
PubMed
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Nef
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nef
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HIV-1 Nef inhibits cleavage of the 45-kDa procaspase-9 to a 35-kDa fragment in BFA-treated MDMs |
PubMed
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nef
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Microarray analyses have shown HIV-1 Nef-induced upregulation of caspase-9 in primary human brain micro vascular endothelial cells |
PubMed
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Tat
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tat
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FasL-induced release of cytochrome c and activation of caspase-9 are inhibited in HIV-1 Tat101-expressing Jurkat cells due to high stability of the mitochondrial inner membrane electrochemical potential |
PubMed
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tat
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HIV-1 Tat activates caspase 9 to induce apoptotic cell death in retinal pigment epithelial cells |
PubMed
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tat
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HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER)-mediated estrogen treatment |
PubMed
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Vpr
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vpr
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HIV-1 Vpr carboxy-terminally truncated form C81, which does not contain the arginine-rich domain (amino acids 82-96), induces apoptosis via the activation of caspase 9 |
PubMed
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vpr
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Virion-associated Vpr activates caspase 3/7, 8, and 9 in Fas-mediated apoptosis in Jurkat T cells and human activated PBMCs |
PubMed
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vpr
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Virion-associated Vpr triggers apoptosis through caspases 3/7 and 9 in human T cells independently of other HIV de novo-expressed proteins and also activates caspase 8, the initiator caspase of the death receptor pathway |
PubMed
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vpr
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Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr |
PubMed
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vpr
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HIV-1 Vpr-induced apoptosis through caspase activation and Smac release from mitochondria is dependent on G2 cell cycle arrest , but is lost in cells synchronized in G1/S |
PubMed
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vpr
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HIV-1 Vpr induces apoptosis through activation of caspase 9 as well as by increasing the overall expression level of caspase 9 |
PubMed
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retropepsin
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gag-pol
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HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP |
PubMed
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