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    DUS1L dihydrouridine synthase 1 like [ Homo sapiens (human) ]

    Gene ID: 64118, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DUS1Lprovided by HGNC
    Official Full Name
    dihydrouridine synthase 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:30086
    See related
    Ensembl:ENSG00000169718 AllianceGenome:HGNC:30086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUS1; PP3111
    Summary
    Enables tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Involved in tRNA dihydrouridine synthesis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 23.4), prostate (RPKM 22.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DUS1L in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82057506..82065804, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82924664..82932962, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80015382..80023680, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DCXR divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80009332-80010001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80022320-80023048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9190 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene MPRA-validated peak3028 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80038893-80039778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80054421-80055336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9192 Neighboring gene fatty acid synthase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9194 Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80061739-80062652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80062653-80063566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80065397-80066310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12989 Neighboring gene coiled-coil domain containing 57 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80074745-80075652 Neighboring gene uncharacterized LOC124904119

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation. Matsuura J, et al. Commun Biol, 2024 Oct 2. PMID 39354220, Free PMC Article
    2. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Finet O, et al. Mol Cell, 2022 Jan 20. PMID 34798057, Free PMC Article
    3. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
    4. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. Chen W, et al. Breast Cancer Res Treat, 2023 Oct. PMID 37433992, Free PMC Article
    5. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Seo HG, et al. Cell Death Dis, 2020 Sep 29. PMID 32994395, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation.
      Title: Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-dihydrouridine16 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA-dihydrouridine17 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA dihydrouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    NP_071439.3
    XP_005256450.1
    XP_005256451.1
    XP_006722351.1
    XP_006722352.1
    XP_024306636.1
    XP_024306637.1
    XP_024306638.1
    XP_024306639.1
    XP_047292475.1
    XP_047292476.1
    XP_047292477.1
    XP_054172862.1
    XP_054172863.1
    XP_054172864.1
    XP_054172865.1
    XP_054172866.1
    XP_054172867.1
    XP_054172868.1
    XP_054172869.1
    XP_054172870.1
    XP_054172871.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022156.5 → NP_071439.3  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

      See identical proteins and their annotated locations for NP_071439.3

      Status: VALIDATED

      Source sequence(s)
      AC135056, BC062566, BC064918, DB481578
      Consensus CDS
      CCDS32775.1
      UniProtKB/Swiss-Prot
      A6NHV4, Q6P1R4, Q96AI3
      Related
      ENSP00000303515.5, ENST00000306796.10
      Conserved Domains (2) summary
      cd02801
      Location:18 → 250
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cl27070
      Location:395 → 429
      DUF702; Domain of unknown function (DUF702)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      82057506..82065804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722289.3 → XP_006722352.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X6

      Conserved Domains (3) summary
      TIGR01623
      Location:377 → 412
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:18 → 233
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:20 → 290
      Dus; Dihydrouridine synthase (Dus)

    2. XM_006722288.3 → XP_006722351.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

      Conserved Domains (2) summary
      cd02801
      Location:18 → 233
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:20 → 290
      Dus; Dihydrouridine synthase (Dus)

    3. XM_024450869.2 → XP_024306637.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

      Conserved Domains (1) summary
      cd02801
      Location:18 → 215
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    4. XM_005256394.3 → XP_005256451.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X8

      Conserved Domains (2) summary
      cd02801
      Location:18 → 250
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:20 → 307
      Dus; Dihydrouridine synthase (Dus)

    5. XM_005256393.3 → XP_005256450.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

      Conserved Domains (2) summary
      cd02801
      Location:18 → 250
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:20 → 307
      Dus; Dihydrouridine synthase (Dus)

    6. XM_024450871.2 → XP_024306639.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X7

      Conserved Domains (1) summary
      cd02801
      Location:18 → 232
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    7. XM_024450870.2 → XP_024306638.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

      Conserved Domains (2) summary
      cd02801
      Location:18 → 232
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cl27070
      Location:412 → 447
      DUF702; Domain of unknown function (DUF702)

    8. XM_024450868.2 → XP_024306636.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

      Conserved Domains (1) summary
      cd02801
      Location:18 → 232
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    9. XM_047436519.1 → XP_047292475.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    10. XM_047436520.1 → XP_047292476.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

    11. XM_047436521.1 → XP_047292477.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

    RNA

    1. XR_002958052.2 RNA Sequence

      Related
      ENST00000582529.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82924664..82932962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316888.1 → XP_054172863.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

    2. XM_054316894.1 → XP_054172869.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X8

    3. XM_054316889.1 → XP_054172864.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

    4. XM_054316887.1 → XP_054172862.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    5. XM_054316892.1 → XP_054172867.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X6

    6. XM_054316890.1 → XP_054172865.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

    7. XM_054316893.1 → XP_054172868.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X7

    8. XM_054316891.1 → XP_054172866.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    9. XM_054316895.1 → XP_054172870.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

    10. XM_054316896.1 → XP_054172871.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

    RNA

    1. XR_008484870.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1R4.1 GenPept UniProtKB/Swiss-Prot:Q6P1R4

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