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    ARHGAP22 Rho GTPase activating protein 22 [ Homo sapiens (human) ]

    Gene ID: 58504, updated on 3-Dec-2024

    Summary

    Official Symbol
    ARHGAP22provided by HGNC
    Official Full Name
    Rho GTPase activating protein 22provided by HGNC
    Primary source
    HGNC:HGNC:30320
    See related
    Ensembl:ENSG00000128805 MIM:610585; AllianceGenome:HGNC:30320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RhoGAP2; RhoGap22
    Summary
    This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARHGAP22 in Genome Data Viewer
    Location:
    10q11.22-q11.23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (48429831..48656265, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49275552..49505563, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49654079..49864310, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:49394772-49395971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49397051-49398006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3329 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49441449-49441950 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49450548-49450771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:49455107-49455608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49495838-49496338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2355 Neighboring gene ribosomal protein S6 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 12210 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:49607374-49608116 Neighboring gene Sharpr-MPRA regulatory region 2186 Neighboring gene Sharpr-MPRA regulatory region 5880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49653211-49654112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49662087-49663064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49668057-49668559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49671373-49672306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49672307-49673238 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49674919-49675115 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49678026-49678908 Neighboring gene Sharpr-MPRA regulatory region 4601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49686951-49687608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49687609-49688265 Neighboring gene Sharpr-MPRA regulatory region 14185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49716013-49716998 Neighboring gene ARHGAP22 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49725473-49726106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727221-49727810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727811-49728398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2356 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49741600-49742140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49750999-49751784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49763487-49763987 Neighboring gene NANOG hESC enhancer GRCh37_chr10:49782573-49783074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3331 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49802653-49803477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49807300-49807800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49812539-49813269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3336 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49887725-49887989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49893168-49893708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49953319-49953863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3340 Neighboring gene WDFY family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3341 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3343 Neighboring gene uncharacterized LOC105378299

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of conduct disorder symptomatology.
    EBI GWAS Catalog
    Genome-wide association study of diabetic retinopathy in a Taiwanese population.
    EBI GWAS Catalog
    The molecular genetic architecture of self-employment.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion HDA PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 22
    Names
    rho-type GTPase-activating protein 22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053158.1 RefSeqGene

      Range
      56193..215230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256024.2NP_001242953.1  rho GTPase-activating protein 22 isoform 1

      See identical proteins and their annotated locations for NP_001242953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC016397, AC016399, BC126444, DB338179
      Consensus CDS
      CCDS58080.1
      UniProtKB/TrEMBL
      A0A2X0SFC0, B3KNU1
      Related
      ENSP00000412461.2, ENST00000417912.6
      Conserved Domains (3) summary
      cd04390
      Location:167365
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:36151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:606694
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001256025.3NP_001242954.1  rho GTPase-activating protein 22 isoform 2

      See identical proteins and their annotated locations for NP_001242954.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AK293579, AY324801, DC391765
      Consensus CDS
      CCDS58081.1
      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000416701.2, ENST00000435790.6
      Conserved Domains (4) summary
      cd04390
      Location:157355
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44150
      PH; PH domain
      cl05005
      Location:556685
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    3. NM_001256026.2NP_001242955.1  rho GTPase-activating protein 22 isoform 4

      See identical proteins and their annotated locations for NP_001242955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, uses an alternate in-frame splice site in a 5' exon, and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC016397, AK127586, DB338179
      Consensus CDS
      CCDS58079.1
      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000410054.2, ENST00000417247.6
      Conserved Domains (4) summary
      cd04390
      Location:61259
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:2954
      PH; PH domain
      cl05005
      Location:460589
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    4. NM_001347735.2NP_001334664.1  rho GTPase-activating protein 22 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399
      UniProtKB/TrEMBL
      B3KNU1
    5. NM_001347736.2NP_001334665.1  rho GTPase-activating protein 22 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC016399, AC068898
      Conserved Domains (1) summary
      cl17171
      Location:4284
      PH-like; Pleckstrin homology-like domain
    6. NM_001347737.2NP_001334666.1  rho GTPase-activating protein 22 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC016399
    7. NM_001347738.2NP_001334667.1  rho GTPase-activating protein 22 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC016397, AC016399, AC068898
      Consensus CDS
      CCDS58081.1
      UniProtKB/TrEMBL
      B3KNU1
    8. NM_021226.4NP_067049.2  rho GTPase-activating protein 22 isoform 3

      See identical proteins and their annotated locations for NP_067049.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared with isoform 1.
      Source sequence(s)
      AY324801
      Consensus CDS
      CCDS7227.1
      UniProtKB/Swiss-Prot
      A0AVP7, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0, Q7Z5H3
      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000249601.4, ENST00000249601.9
      Conserved Domains (4) summary
      cd04390
      Location:151349
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:36151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:38144
      PH; PH domain
      cl05005
      Location:550679
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RNA

    1. NR_045675.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains alternate 5' exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016397, AK055937, DB338179
      Related
      ENST00000460425.1
    2. NR_144642.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399
    3. NR_144643.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399
    4. NR_144644.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399
    5. NR_144645.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399
    6. NR_144646.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      48429831..48656265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448100.2XP_024303868.1  rho GTPase-activating protein 22 isoform X14

      Conserved Domains (2) summary
      cd04390
      Location:157347
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    2. XM_011540013.4XP_011538315.1  rho GTPase-activating protein 22 isoform X12

      Conserved Domains (3) summary
      cd04390
      Location:173363
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44150
      PH; PH domain
    3. XM_017016476.2XP_016871965.1  rho GTPase-activating protein 22 isoform X16

    4. XM_011540003.2XP_011538305.1  rho GTPase-activating protein 22 isoform X1

      See identical proteins and their annotated locations for XP_011538305.1

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (3) summary
      cd04390
      Location:173371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:612700
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_011540006.3XP_011538308.1  rho GTPase-activating protein 22 isoform X5

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (4) summary
      cd04390
      Location:114312
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:44111
      PH; PH domain
      cl05005
      Location:513642
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:42127
      PH-like; Pleckstrin homology-like domain
    6. XM_047425586.1XP_047281542.1  rho GTPase-activating protein 22 isoform X2

      UniProtKB/TrEMBL
      B3KNU1
    7. XM_011540015.4XP_011538317.1  rho GTPase-activating protein 22 isoform X17

      Conserved Domains (3) summary
      cd04390
      Location:173351
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44150
      PH; PH domain
    8. XM_011540002.3XP_011538304.1  rho GTPase-activating protein 22 isoform X1

      See identical proteins and their annotated locations for XP_011538304.1

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (3) summary
      cd04390
      Location:173371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:612700
      SMC_N; RecF/RecN/SMC N terminal domain
    9. XM_024448099.2XP_024303867.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (3) summary
      cd04390
      Location:173371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:612700
      SMC_N; RecF/RecN/SMC N terminal domain
    10. XM_011540011.3XP_011538313.1  rho GTPase-activating protein 22 isoform X10

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (2) summary
      cd04390
      Location:18216
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cl05005
      Location:417546
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    11. XM_047425589.1XP_047281545.1  rho GTPase-activating protein 22 isoform X8

      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000363285.1, ENST00000374170.5
    12. XM_005270014.4XP_005270071.1  rho GTPase-activating protein 22 isoform X6

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (4) summary
      cd04390
      Location:77275
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:2954
      PH; PH domain
      cl05005
      Location:476605
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    13. XM_011540005.2XP_011538307.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000363287.1, ENST00000374172.5
      Conserved Domains (4) summary
      cd04390
      Location:77275
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:2954
      PH; PH domain
      cl05005
      Location:476605
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    14. XM_047425588.1XP_047281544.1  rho GTPase-activating protein 22 isoform X7

      UniProtKB/TrEMBL
      B3KNU1
    15. XM_047425590.1XP_047281546.1  rho GTPase-activating protein 22 isoform X9

      UniProtKB/TrEMBL
      B3KNU1
    16. XM_047425591.1XP_047281547.1  rho GTPase-activating protein 22 isoform X9

      UniProtKB/TrEMBL
      B3KNU1
    17. XM_047425587.1XP_047281543.1  rho GTPase-activating protein 22 isoform X3

    18. XM_017016471.3XP_016871960.1  rho GTPase-activating protein 22 isoform X11

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (2) summary
      cd04390
      Location:5203
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cl05005
      Location:404533
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    19. XM_047425593.1XP_047281549.1  rho GTPase-activating protein 22 isoform X15

    20. XM_047425592.1XP_047281548.1  rho GTPase-activating protein 22 isoform X13

    21. XM_047425594.1XP_047281550.1  rho GTPase-activating protein 22 isoform X18

      UniProtKB/TrEMBL
      D6RBJ8
    22. XM_047425595.1XP_047281551.1  rho GTPase-activating protein 22 isoform X20

    23. XM_024448102.2XP_024303870.1  rho GTPase-activating protein 22 isoform X19

      Conserved Domains (1) summary
      cl17171
      Location:42130
      PH-like; Pleckstrin homology-like domain
    24. XM_024448106.2XP_024303874.1  rho GTPase-activating protein 22 isoform X21

      Conserved Domains (1) summary
      cl17171
      Location:4284
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      49275552..49505563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366471.1XP_054222446.1  rho GTPase-activating protein 22 isoform X14

    2. XM_054366469.1XP_054222444.1  rho GTPase-activating protein 22 isoform X12

    3. XM_054366473.1XP_054222448.1  rho GTPase-activating protein 22 isoform X16

    4. XM_054366457.1XP_054222432.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KNU1
    5. XM_054366458.1XP_054222433.1  rho GTPase-activating protein 22 isoform X2

      UniProtKB/TrEMBL
      B3KNU1
    6. XM_054366455.1XP_054222430.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KNU1
    7. XM_054366461.1XP_054222436.1  rho GTPase-activating protein 22 isoform X5

      UniProtKB/TrEMBL
      B3KNU1
    8. XM_054366474.1XP_054222449.1  rho GTPase-activating protein 22 isoform X17

    9. XM_054366456.1XP_054222431.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KNU1
    10. XM_054366464.1XP_054222439.1  rho GTPase-activating protein 22 isoform X8

      UniProtKB/TrEMBL
      B3KNU1
    11. XM_054366462.1XP_054222437.1  rho GTPase-activating protein 22 isoform X6

      UniProtKB/TrEMBL
      B3KNU1
    12. XM_054366460.1XP_054222435.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      B3KNU1
    13. XM_054366463.1XP_054222438.1  rho GTPase-activating protein 22 isoform X7

      UniProtKB/TrEMBL
      B3KNU1
    14. XM_054366465.1XP_054222440.1  rho GTPase-activating protein 22 isoform X9

      UniProtKB/TrEMBL
      B3KNU1
    15. XM_054366468.1XP_054222443.1  rho GTPase-activating protein 22 isoform X22

      UniProtKB/TrEMBL
      B3KNU1
    16. XM_054366466.1XP_054222441.1  rho GTPase-activating protein 22 isoform X9

      UniProtKB/TrEMBL
      B3KNU1
    17. XM_054366459.1XP_054222434.1  rho GTPase-activating protein 22 isoform X3

    18. XM_054366467.1XP_054222442.1  rho GTPase-activating protein 22 isoform X11

      UniProtKB/TrEMBL
      B3KNU1
    19. XM_054366472.1XP_054222447.1  rho GTPase-activating protein 22 isoform X15

    20. XM_054366470.1XP_054222445.1  rho GTPase-activating protein 22 isoform X13

    21. XM_054366475.1XP_054222450.1  rho GTPase-activating protein 22 isoform X18

      UniProtKB/TrEMBL
      D6RBJ8
    22. XM_054366477.1XP_054222452.1  rho GTPase-activating protein 22 isoform X23

    23. XM_054366479.1XP_054222454.1  rho GTPase-activating protein 22 isoform X20

    24. XM_054366476.1XP_054222451.1  rho GTPase-activating protein 22 isoform X23

    25. XM_054366478.1XP_054222453.1  rho GTPase-activating protein 22 isoform X19

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001256027.1: Suppressed sequence

      Description
      NM_001256027.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.