Nr1d2 nuclear receptor subfamily 1, group D, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr1d2provided by MGI
Official Full Name: nuclear receptor subfamily 1, group D, member 2provided by MGI
Primary source: MGI:MGI:2449205
See related: Ensembl:ENSMUSG00000021775 AllianceGenome:MGI:2449205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RVR; Rev-erb
Summary: This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]
Expression: Broad expression in bladder adult (RPKM 22.5), cerebellum adult (RPKM 19.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 7.08 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (4230549..4265639)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (18204056..18239106, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology.
Title: Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology.
Circadian Clock Component Rev-erbalpha Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
Title: Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
Dysregulation of REV-ERBalpha impairs GABAergic function and promotes epileptic seizures in preclinical models.
Title: Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Pharmacological modulation and genetic deletion of REV-ERBalpha and REV-ERBbeta regulates dendritic cell development.
Title: Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development.
Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease.
Title: Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease.
this study showsev-erbalpha negatively regulated osteoclast and osteoblast differentiation by suppressing the p38 MAPK pathway
Title: Rev-erbα Negatively Regulates Osteoclast and Osteoblast Differentiation through p38 MAPK Signaling Pathway.
Rev-erbalpha is a pharmacologically accessible link between the circadian clock and neuroinflammation.
Title: Circadian clock protein Rev-erbα regulates neuroinflammation.
results proved that the REV-ERB agonism inhibited osteoclastogenesis partially via FABP4 up-regulation.
Title: REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
REV-ERBbeta is involved in the maintenance of wakefulness during the activity period of the circadian rhythm.
Title: REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009.
REV-ERBbeta drives mitochondrial biogenesis and the expression of genes involved in fatty acid oxidation. REV-ERBbeta-deficient mice exhibited an altered metabolic phenotype compared to wild-type littermates. REV-ERBbeta plays a role in the control of skeletal muscle metabolism and energy expenditure
Title: Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nr1d2 (e-PCR), detects polymorphism
- UniSTS:546583

Nr1d2 (e-PCR), detects polymorphism
- UniSTS:507099

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear receptor subfamily 1 group D member 2

Names: Rev-erb beta; orphan nuclear receptor RVR; rev-erb-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425894.1 → NP_001412823.1 nuclear receptor subfamily 1 group D member 2 isoform 2

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425895.1 → NP_001412824.1 nuclear receptor subfamily 1 group D member 2 isoform 3

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425896.1 → NP_001412825.1 nuclear receptor subfamily 1 group D member 2 isoform 4

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425897.1 → NP_001412826.1 nuclear receptor subfamily 1 group D member 2 isoform 5

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425898.1 → NP_001412827.1 nuclear receptor subfamily 1 group D member 2 isoform 6

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425900.1 → NP_001412829.1 nuclear receptor subfamily 1 group D member 2 isoform 7

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425901.1 → NP_001412830.1 nuclear receptor subfamily 1 group D member 2 isoform 7

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425902.1 → NP_001412831.1 nuclear receptor subfamily 1 group D member 2 isoform 8

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425903.1 → NP_001412832.1 nuclear receptor subfamily 1 group D member 2 isoform 9

Status: VALIDATED

Source sequence(s)

CU024892
NM_001425904.1 → NP_001412833.1 nuclear receptor subfamily 1 group D member 2 isoform 10

Status: VALIDATED

Source sequence(s)

CU024892
NM_011584.5 → NP_035714.3 nuclear receptor subfamily 1 group D member 2 isoform 1

See identical proteins and their annotated locations for NP_035714.3

Status: VALIDATED

Source sequence(s)

CU024892

Consensus CDS

CCDS36811.1

UniProtKB/Swiss-Prot

Q60646, Q60674

UniProtKB/TrEMBL

Q4VAB7, Q8C598

Related

ENSMUSP00000088031.6, ENSMUST00000090543.6

Conserved Domains (2) summary

cd06940
Location:386 → 574

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:98 → 186

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

4230549..4265639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158687.1 → XP_036014580.1 nuclear receptor subfamily 1 group D member 2 isoform X1

UniProtKB/TrEMBL

Q8C598

Conserved Domains (2) summary

cd07166
Location:98 → 186

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

cl11397
Location:386 → 512

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators