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    tgfbr2b transforming growth factor beta receptor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 30739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tgfbr2bprovided by ZNC
    Official Full Name
    transforming growth factor beta receptor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-375
    See related
    Ensembl:ENSDARG00000034541 AllianceGenome:ZFIN:ZDB-GENE-980526-375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb537; tgfbr2; wu:fj05c10; zgc:110498
    Summary
    Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in membrane raft. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and trigeminal ganglion. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tgfbr2b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (39505163..39570831, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (39555131..39620799, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 10b Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit B Neighboring gene uncharacterized LOC137487951 Neighboring gene RNA binding motif, single stranded interacting protein Neighboring gene uncharacterized LOC137487952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. TGFβ (transforming growth factor β) and keratocyte motility in 24 h zebrafish explant cultures. Tan B, et al. Cell Biol Int, 2011 Nov. PMID 21729005
    2. Cloning of transforming growth factor-beta 1 (TGF-beta 1) and its type II receptor from zebrafish ovary and role of TGF-beta 1 in oocyte maturation. Kohli G, et al. Endocrinology, 2003 May. PMID 12697700
    3. Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. Kim Y, et al. J Hazard Mater, 2020 Apr 15. PMID 31806443
    4. RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish. Clements TP, et al. Genesis, 2017 Aug. PMID 28653435, Free PMC Article
    5. An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation. Dobrzycki T, et al. Biol Open, 2018 Apr 9. PMID 29535102, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The zebrafish T beta RII cDNA sequence is the first to be reported from a fish species, and it shows a high level of conservation at the kinase domain. mRNA expression of TGF-beta 1, T beta RII.
      Title: Cloning of transforming growth factor-beta 1 (TGF-beta 1) and its type II receptor from zebrafish ovary and role of TGF-beta 1 in oocyte maturation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110498

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables activin receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type I transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta receptor type-2
    Names
    TGF-beta receptor 2
    transforming growth factor, beta receptor II
    transforming growth factor-beta receptor 2
    NP_878275.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182855.3 → NP_878275.2  TGF-beta receptor type-2 precursor

      See identical proteins and their annotated locations for NP_878275.2

      Status: PROVISIONAL

      Source sequence(s)
      BC091807
      UniProtKB/TrEMBL
      Q58EQ1
      Related
      ENSDARP00000039831.5, ENSDART00000039832.6
      Conserved Domains (3) summary
      smart00221
      Location:232 → 520
      STYKc; Protein kinase; unclassified specificity
      cd14055
      Location:237 → 528
      STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
      pfam08917
      Location:39 → 139
      ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      39505163..39570831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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