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    ctss1 cathepsin S, ortholog 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393398, updated on 27-Dec-2024

    Summary

    Official Symbol
    ctss1provided by ZNC
    Official Full Name
    cathepsin S, ortholog 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1583
    See related
    Ensembl:ENSDARG00000036940 AllianceGenome:ZFIN:ZDB-GENE-040426-1583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctssa; zgc:66267
    Summary
    Predicted to enable cysteine-type peptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ctss1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (306949..317527)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (310165..317320)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene sodium channel, voltage-gated, type I, beta b Neighboring gene synaptic Ras GTPase activating protein 1a Neighboring gene leucine rich repeat and Ig domain containing 4a Neighboring gene glycerol-3-phosphate dehydrogenase 1c Neighboring gene golgi phosphoprotein 3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC66267

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cathepsin S, ortholog 1
    Names
    cathepsin S, a
    cathepsin Sa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200426.2NP_956720.2  cathepsin S, ortholog 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CR548627
      UniProtKB/TrEMBL
      A0A8M6YUF9, A0A8M6YWB3, Q1L8W8
      Related
      ENSDARP00000053637.5, ENSDART00000053638.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      306949..317527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215047.1XP_068071148.1  cathepsin S, ortholog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YUF9, A0A8M6YWB3, Q1L8W8
    2. XM_068215045.1XP_068071146.1  cathepsin S, ortholog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YUF9
    3. XM_068215046.1XP_068071147.1  cathepsin S, ortholog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YUF9, A0A8M6YWB3, Q1L8W8
    4. XM_017352203.3XP_017207692.2  cathepsin S, ortholog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YUF9