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    anapc4 anaphase promoting complex subunit 4 [ Danio rerio (zebrafish) ]

    Gene ID: 494046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    anapc4provided by ZNC
    Official Full Name
    anaphase promoting complex subunit 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-10
    See related
    Ensembl:ENSDARG00000032237 AllianceGenome:ZFIN:ZDB-GENE-041212-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101872; si:dkey-90m5.2
    Summary
    Predicted to be involved in anaphase-promoting complex-dependent catabolic process and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See anapc4 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (23475381..23494706, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (23576264..23595614, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-90m5.4 Neighboring gene solute carrier family 10 member 4 Neighboring gene SLAIN motif family, member 2 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene carbonyl reductase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008589.1 → NP_001008589.1  anaphase-promoting complex subunit 4

      See identical proteins and their annotated locations for NP_001008589.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086751
      UniProtKB/TrEMBL
      A0A8M1N3K4, Q5PR93
      Related
      ENSDARP00000058523.2, ENSDART00000058524.5
      Conserved Domains (2) summary
      pfam12894
      Location:3 → 50
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:217 → 416
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      23475381..23494706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215430.1 → XP_068071531.1  anaphase-promoting complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M1N3K4, Q5PR93

    2. XM_009294660.4 → XP_009292935.1  anaphase-promoting complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AW62
      Conserved Domains (2) summary
      pfam12894
      Location:3 → 50
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:224 → 423
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

    3. XM_005160520.4 → XP_005160577.1  anaphase-promoting complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_005160577.1

      UniProtKB/TrEMBL
      A0A8M2B7D6
      Conserved Domains (2) summary
      pfam12894
      Location:3 → 50
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:226 → 425
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

    4. XM_017352471.3 → XP_017207960.1  anaphase-promoting complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7D6
      Conserved Domains (2) summary
      pfam12894
      Location:3 → 50
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:226 → 425
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

    5. XM_068215429.1 → XP_068071530.1  anaphase-promoting complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AW62

    6. XM_005160521.4 → XP_005160578.1  anaphase-promoting complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_005160578.1

      UniProtKB/TrEMBL
      A0A8M2B7D6
      Conserved Domains (2) summary
      pfam12894
      Location:3 → 50
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:226 → 425
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

    7. XM_005160522.4 → XP_005160579.1  anaphase-promoting complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_005160579.1

      UniProtKB/TrEMBL
      A0A8M2B7D6
      Conserved Domains (2) summary
      pfam12894
      Location:3 → 50
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:226 → 425
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
    Nucleotide Protein
    Heading Accession and Version

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