tenm3 teneurin transmembrane protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tenm3provided by ZNC
Official Full Name: teneurin transmembrane protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-19
See related: Ensembl:ENSDARG00000005479 AllianceGenome:ZFIN:ZDB-GENE-990714-19
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: odz3; cb399; ten-3; srs334; ten-m3; id:ibd3379; zgc:153720; id:ibd3379m
Summary: Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within dendrite guidance; retinal ganglion cell axon guidance; and visual perception. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including fin bud; immature eye; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (39060841..39779913)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (38862055..39059405)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

G39964 (e-PCR)
- UniSTS:81674

tenm3 (e-PCR)
- UniSTS:205492

fc68f07.y1 (e-PCR)
- UniSTS:194253

G39935 (e-PCR)
- UniSTS:70637

fb07d06.y1 (e-PCR)
- UniSTS:189940

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of homophilic cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: teneurin-3

Names: odd oz/ten-m3; odz, odd Oz/ten-m homolog 3; seizure resistant s334; tenascin-M3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365543.1 → NP_001352472.1 teneurin-3

Status: VALIDATED

Source sequence(s)

BX005481, BX322797, BX324137, BX324208

UniProtKB/Swiss-Prot

E7EYS1, Q9W7R4

Conserved Domains (11) summary

COG3209
Location:1480 → 2038

RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]

cd00054
Location:753 → 782

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd05819
Location:1184 → 1223

NHL; NHL repeat [structural motif]

TIGR01643
Location:1839 → 1879

YD_repeat_2x; YD repeat (two copies)

pfam07974
Location:512 → 538

EGF_2; EGF-like domain

cl18310
Location:1155 → 1514

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:2223 → 2260

RHS_repeat; RHS Repeat

pfam06484
Location:11 → 305

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2634 → 2709

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl26067
Location:581 → 712

Keratin_B2; Keratin, high sulfur B2 protein

cl27255
Location:2334 → 2412

RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]