pax5 paired box 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pax5provided by ZNC
Official Full Name: paired box 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-001030-2
See related: Ensembl:ENSDARG00000037383 AllianceGenome:ZFIN:ZDB-GENE-001030-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: noi; pax2a; pax2.1; paxzf-b; Pax[Zf-b]
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within vestibular receptor cell development and vestibular reflex. Predicted to be located in nucleus. Is expressed in several structures, including chordo neural hinge; hindbrain neural keel; immune system; midbrain hindbrain boundary neural keel; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human PAX5 (paired box 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (21725821..21825595)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (21032866..21122932)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pax5 works in conjunction with fgf3 and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function.
Title: Zebrafish pax5 regulates development of the utricular macula and vestibular function.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vestibular receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vestibular reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paired box protein Pax-5

Names: No isthmus protein; paired box gene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131638.2 → NP_571713.1 paired box protein Pax-5

Status: VALIDATED

Source sequence(s)

BX511134

UniProtKB/TrEMBL

A0A8M1PBT6, F1QGF8

Related

ENSDARP00000114412.1, ENSDART00000132602.3

Conserved Domains (1) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

21725821..21825595

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170922.5 → XP_005170979.1 paired box protein Pax-5 isoform X1

UniProtKB/TrEMBL

A0A8M2BI63

Conserved Domains (2) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:280 → 403

Pax2_C; Paired-box protein 2 C terminal
XM_005170923.5 → XP_005170980.1 paired box protein Pax-5 isoform X2

UniProtKB/TrEMBL

A0A8M2BI96

Related

ENSDARP00000054394.5, ENSDART00000054395.6

Conserved Domains (2) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:279 → 402

Pax2_C; Paired-box protein 2 C terminal