U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    skia v-ski avian sarcoma viral oncogene homolog a [ Danio rerio (zebrafish) ]

    Gene ID: 30101, updated on 9-Dec-2024

    Summary

    Official Symbol
    skiaprovided by ZNC
    Official Full Name
    v-ski avian sarcoma viral oncogene homolog aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990715-9
    See related
    Ensembl:ENSDARG00000042151 AllianceGenome:ZFIN:ZDB-GENE-990715-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    id:ibd1250
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within cardiac conduction; cartilage development; and regionalization. Located in nucleus. Is expressed in several structures, including brain; lens; presumptive diencephalon; solid lens vesicle; and tail bud. Used to study craniosynostosis. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See skia in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (17395928..17516446, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (17360216..17480734, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) Neighboring gene uncharacterized LOC137496333 Neighboring gene uncharacterized LOC137496334 Neighboring gene si:ch73-70k4.1 Neighboring gene protein kinase C, zeta Neighboring gene uncharacterized LOC137496335

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC136741

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables SMAD binding  
    enables SMAD binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    v-ski avian sarcoma viral oncogene homolog a
    Names
    nuclear oncoprotein skia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130935.3 → NP_571010.3  v-ski avian sarcoma viral oncogene homolog a

      Status: VALIDATED

      Source sequence(s)
      BX664713, CT573407, CU571083
      UniProtKB/TrEMBL
      Q1ECW8
      Related
      ENSDARP00000091440.4, ENSDART00000100667.5
      Conserved Domains (3) summary
      smart01046
      Location:198 → 293
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:75 → 173
      Ski_Sno; SKI/SNO/DAC family
      cl25732
      Location:532 → 705
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      17395928..17516446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394717.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      50111..51419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.