fzd10 frizzled class receptor 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd10provided by ZNC
Official Full Name: frizzled class receptor 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-220
See related: Ensembl:ENSDARG00000068213 AllianceGenome:ZFIN:ZDB-GENE-990415-220
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz4; fzb; zg04; fk48e04; wu:fk48e04
Summary: Enables Wnt receptor activity. Acts upstream of or within Wnt signaling pathway and epiboly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; central nervous system; forerunner cell group; margin; and tail bud. Orthologous to human FZD10 (frizzled class receptor 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (44295983..44298964, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (44302564..44305545, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	IMP Inferred from Mutant Phenotype more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epiboly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: frizzled-10

Names: frizzled homolog 10; frizzled homolog 4; frizzled homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130917.2 → NP_570992.2 frizzled-10 precursor

See identical proteins and their annotated locations for NP_570992.2

Status: VALIDATED

Source sequence(s)

BC076546

UniProtKB/TrEMBL

B2GT13, F6P1N0, Q9W6E3

Related

ENSDARP00000089291.2, ENSDART00000098520.4

Conserved Domains (2) summary

cd15037
Location:217 → 535

7tmF_FZD10; class F frizzled subfamily 10, member of 7-transmembrane G protein-coupled receptors

cl02447
Location:31 → 157

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain