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    bin2b bridging integrator 2b [ Danio rerio (zebrafish) ]

    Gene ID: 327387, updated on 4-Jan-2025

    Summary

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    Official Symbol
    bin2bprovided by ZNC
    Official Full Name
    bridging integrator 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5598
    See related
    Ensembl:ENSDARG00000010255 AllianceGenome:ZFIN:ZDB-GENE-030131-5598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    BIN2; bin2l; zgc:55758; wu:fi05e01
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be involved in phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Orthologous to human BIN2 (bridging integrator 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See bin2b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (38880189..38893469)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (38882638..38895966)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 35, like Neighboring gene uncharacterized LOC137495995 Neighboring gene solute carrier family 48 member 1b Neighboring gene histone deacetylase 7b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in podosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with phagocytic cup IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in podosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bridging integrator 2b
    Names
    bridging integrator 2, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199796.1 → NP_956090.1  bridging integrator 2b

      See identical proteins and their annotated locations for NP_956090.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044473
      UniProtKB/TrEMBL
      Q803I3
      Related
      ENSDARP00000015168.7, ENSDART00000019939.9
      Conserved Domains (2) summary
      cd07612
      Location:38 → 248
      BAR_Bin2; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
      cl17036
      Location:452 → 522
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      38880189..38893469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166011.5 → XP_005166068.1  bridging integrator 2b isoform X1

      See identical proteins and their annotated locations for XP_005166068.1

      UniProtKB/TrEMBL
      A0A8M2BDB7, F1QJB5
      Conserved Domains (2) summary
      cd07612
      Location:38 → 248
      BAR_Bin2; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
      cl17036
      Location:452 → 522
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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