csk C-terminal Src kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cskprovided by ZNC
Official Full Name: C-terminal Src kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061103-493
See related: Ensembl:ENSDARG00000067996 AllianceGenome:ZFIN:ZDB-GENE-061103-493
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:154049
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (20601653..20666202, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (20503999..20568548, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src, which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
Title: Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.

Submit: New GeneRIF Correction

General gene information

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Markers

fb81b08.x1 (e-PCR)
- UniSTS:191608

fb81b08.x1 (e-PCR)
- UniSTS:191609

G45090 (e-PCR)
- UniSTS:105892

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase CSK

Names: c-src tyrosine kinase

NP_001071067.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077599.1 → NP_001071067.1 tyrosine-protein kinase CSK

See identical proteins and their annotated locations for NP_001071067.1

Status: PROVISIONAL

Source sequence(s)

BC125943

UniProtKB/TrEMBL

A0A8N7XJM0, A0JMN4, B2GSN7, E7FAC6

Related

ENSDARP00000088849.4, ENSDART00000098076.5

Conserved Domains (4) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

smart00221
Location:195 → 440

STYKc; Protein kinase; unclassified specificity