stau1 staufen double-stranded RNA binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stau1provided by ZNC
Official Full Name: staufen double-stranded RNA binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6372
See related: Ensembl:ENSDARG00000044182 AllianceGenome:ZFIN:ZDB-GENE-030131-6372
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi67e05; zgc:77271; wu:fi67e05
Summary: Enables mRNA binding activity. Acts upstream of or within germ cell development. Located in cortical granule and germinal vesicle. Is expressed in brain; gonad; musculature system; and neural tube. Orthologous to human STAU1 (staufen double-stranded RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (46431848..46454823)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (46429796..46452941)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings suggest that cyclin B1 mRNA-Staufen1 protein complexes are transported toward the animal pole of zebrafish oocytes by the plus-end-directed motor protein Kinesin1 along microtubules, and that a common mRNA transport machinery functions in zebrafish and Xenopus oocytes, although its transport direction is opposite due to different organizations of microtubules.
Title: Staufen1, Kinesin1 and microtubule function in cyclin B1 mRNA transport to the animal polar cytoplasm of zebrafish oocytes.
Maternally expressed staufen is dispersed in the mature oocyte and early embryo. In the adult, staufen is expressed in specific brain nuclei, the testis, neurons and Leydig cells
Title: Expression of the zebrafish Staufen gene in the embryo and adult.
stau1 is required for the survival and migration of primordial germ cells.
Title: Zebrafish Staufen1 and Staufen2 are required for the survival and migration of primordial germ cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cortical granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in germinal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: double-stranded RNA-binding protein Staufen homolog 1

Names: staufen, RNA binding protein, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205561.2 → NP_991124.2 double-stranded RNA-binding protein Staufen homolog 1

Status: VALIDATED

Source sequence(s)

AI877575, BX546446, EB896609

UniProtKB/TrEMBL

A0A2R8Q731, A0A8M1PJS2

Related

ENSDARP00000148866.1, ENSDART00000181056.1

Conserved Domains (3) summary

smart00358
Location:287 → 350

DSRM; Double-stranded RNA binding motif

cd00048
Location:387 → 453

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:551 → 660

Staufen_C; Staufen C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

46431848..46454823

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168759.5 → XP_005168816.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1

See identical proteins and their annotated locations for XP_005168816.1

UniProtKB/TrEMBL

A0A2R8Q731, A0A8M1PJS2

Conserved Domains (3) summary

smart00358
Location:287 → 350

DSRM; Double-stranded RNA binding motif

cd00048
Location:387 → 453

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:551 → 660

Staufen_C; Staufen C-terminal domain
XM_005168761.5 → XP_005168818.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8M2BG12, F1Q5V4

Related

ENSDARP00000116967.1, ENSDART00000133992.3

Conserved Domains (3) summary

smart00358
Location:275 → 338

DSRM; Double-stranded RNA binding motif

cd00048
Location:375 → 441

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:539 → 648

Staufen_C; Staufen C-terminal domain