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    hipk3a homeodomain interacting protein kinase 3a [ Danio rerio (zebrafish) ]

    Gene ID: 564413, updated on 4-Jan-2025

    Summary

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    Official Symbol
    hipk3aprovided by ZNC
    Official Full Name
    homeodomain interacting protein kinase 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061207-54
    See related
    Ensembl:ENSDARG00000062469 AllianceGenome:ZFIN:ZDB-GENE-061207-54
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-21k24.2
    Summary
    Predicted to enable ATP binding activity; DNA binding activity; and protein serine/threonine kinase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See hipk3a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (15287036..15351444)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (15190482..15255044)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 73 Neighboring gene t-complex 11, testis-specific-like 1 Neighboring gene KIAA1549-like a Neighboring gene uncharacterized LOC566482

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144047.1 → NP_001137519.1  homeodomain-interacting protein kinase 3a

      Status: PROVISIONAL

      Source sequence(s)
      BX322616
      UniProtKB/TrEMBL
      A0A8M1NT10, A0A8M3AWI1, F6NWN5
      Related
      ENSDARP00000117279.1, ENSDART00000147572.3
      Conserved Domains (2) summary
      smart00220
      Location:233 → 561
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:232 → 561
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      15287036..15351444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470504.2 → XP_021326179.1  homeodomain-interacting protein kinase 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PGV2, A0A8M9PMR8
      Conserved Domains (2) summary
      pfam12881
      Location:601 → 737
      NUT; NUT protein
      cl21453
      Location:232 → 561
      PKc_like; Protein Kinases, catalytic domain

    2. XM_068217397.1 → XP_068073498.1  homeodomain-interacting protein kinase 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PGV2
    Nucleotide Protein Strain
    Heading Accession and Version

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