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    srsf7a serine and arginine rich splicing factor 7a [ Danio rerio (zebrafish) ]

    Gene ID: 402972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srsf7aprovided by ZNC
    Official Full Name
    serine and arginine rich splicing factor 7aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1798
    See related
    Ensembl:ENSDARG00000035325 AllianceGenome:ZFIN:ZDB-GENE-040426-1798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb39b02; zgc:77155; wu:fb39b02
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to be active in nuclear speck. Orthologous to human SRSF7 (serine and arginine rich splicing factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See srsf7a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (36895607..36899144)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36295418..36298991)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene P1, F-box associated domain containing Neighboring gene solute carrier family 8 member 2a Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene kaptin (actin binding protein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High resolution annotation of zebrafish transcriptome using long-read sequencing. Nudelman G, et al. Genome Res, 2018 Sep. PMID 30061115, Free PMC Article
    2. Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Lawir DF, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571908, Free PMC Article
    3. Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. Gangras P, et al. PLoS Genet, 2020 Jun. PMID 32502192, Free PMC Article
    4. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
    5. On the tubulin polymerization promoting proteins of zebrafish. Orosz F. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25576359

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77155

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine and arginine rich splicing factor 7a
    Names
    serine/arginine-rich splicing factor 7a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205673.1 → NP_991236.1  serine and arginine rich splicing factor 7a

      See identical proteins and their annotated locations for NP_991236.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065586
      UniProtKB/TrEMBL
      A0A8M2BCQ8, Q6P0K2
      Related
      ENSDARP00000121453.1, ENSDART00000135776.3
      Conserved Domains (2) summary
      cd12373
      Location:15 → 87
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
      pfam00098
      Location:108 → 121
      zf-CCHC; Zinc knuckle

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      36895607..36899144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165292.5 → XP_005165349.1  serine and arginine rich splicing factor 7a isoform X2

      See identical proteins and their annotated locations for XP_005165349.1

      UniProtKB/TrEMBL
      A0A8M2BCI7, A2BHB2
      Related
      ENSDARP00000113076.1, ENSDART00000141984.3
      Conserved Domains (2) summary
      cd12373
      Location:15 → 87
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
      pfam00098
      Location:108 → 121
      zf-CCHC; Zinc knuckle

    2. XM_005165288.5 → XP_005165345.1  serine and arginine rich splicing factor 7a isoform X1

      See identical proteins and their annotated locations for XP_005165345.1

      UniProtKB/TrEMBL
      A0A8M2BCQ8, Q6P0K2
      Related
      ENSDARP00000051184.5, ENSDART00000051185.7
      Conserved Domains (2) summary
      cd12373
      Location:15 → 87
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
      pfam00098
      Location:108 → 121
      zf-CCHC; Zinc knuckle

    3. XM_005165291.5 → XP_005165348.1  serine and arginine rich splicing factor 7a isoform X2

      See identical proteins and their annotated locations for XP_005165348.1

      UniProtKB/TrEMBL
      A0A8M2BCI7, A2BHB2
      Related
      ENSDARP00000115725.1, ENSDART00000133842.3
      Conserved Domains (2) summary
      cd12373
      Location:15 → 87
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
      pfam00098
      Location:108 → 121
      zf-CCHC; Zinc knuckle

    4. XM_005165289.2 → XP_005165346.1  serine and arginine rich splicing factor 7a isoform X1

      See identical proteins and their annotated locations for XP_005165346.1

      UniProtKB/TrEMBL
      A0A8M2BCQ8, Q6P0K2
      Related
      ENSDARP00000113600.1, ENSDART00000134493.3
      Conserved Domains (2) summary
      cd12373
      Location:15 → 87
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
      pfam00098
      Location:108 → 121
      zf-CCHC; Zinc knuckle

    5. XM_005165293.2 → XP_005165350.1  serine and arginine rich splicing factor 7a isoform X2

      See identical proteins and their annotated locations for XP_005165350.1

      UniProtKB/TrEMBL
      A0A8M2BCI7, A2BHB2
      Conserved Domains (2) summary
      cd12373
      Location:15 → 87
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
      pfam00098
      Location:108 → 121
      zf-CCHC; Zinc knuckle

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394595.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      136622..140159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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