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    cnot3a CCR4-NOT transcription complex, subunit 3a [ Danio rerio (zebrafish) ]

    Gene ID: 449540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cnot3aprovided by ZNC
    Official Full Name
    CCR4-NOT transcription complex, subunit 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040927-6
    See related
    Ensembl:ENSDARG00000007135 AllianceGenome:ZFIN:ZDB-GENE-040927-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cnot3; fb73b06; fc17h07; zgc:92813; wu:fb73b06; wu:fc17h07
    Summary
    Acts upstream of or within digestive tract development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cnot3a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32110195..32128345, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32156165..32174333, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene PRP31 pre-mRNA processing factor 31 homolog (yeast) Neighboring gene uncharacterized LOC137487923 Neighboring gene sphingosine kinase 2 Neighboring gene G protein-coupled receptor, class C, group 6, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. Delacruz RGC, et al. Oncotarget, 2019 Jun 11. PMID 31231471, Free PMC Article
    2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of stem cell population maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 3a
    Names
    CCR4-NOT transcription complex, subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328118.1 → NP_001315047.1  CCR4-NOT transcription complex subunit 3a

      Status: VALIDATED

      Source sequence(s)
      CR854927
      UniProtKB/TrEMBL
      A0A8M1P9K0, F1Q4L8
      Related
      ENSDARP00000092876.3, ENSDART00000102100.3
      Conserved Domains (2) summary
      pfam04065
      Location:3 → 229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:779 → 900
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      32110195..32128345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466678.2 → XP_021322353.1  CCR4-NOT transcription complex subunit 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9P7W2
      Conserved Domains (3) summary
      pfam04065
      Location:3 → 227
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:773 → 898
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
      cl26464
      Location:536 → 821
      Atrophin-1; Atrophin-1 family

    2. XM_005158349.5 → XP_005158406.1  CCR4-NOT transcription complex subunit 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4P9, E9QGK5
      Related
      ENSDARP00000118084.1, ENSDART00000137699.3
      Conserved Domains (2) summary
      pfam04065
      Location:3 → 229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:772 → 893
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005582.1: Suppressed sequence

      Description
      NM_001005582.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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