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    rtn1b reticulon 1b [ Danio rerio (zebrafish) ]

    Gene ID: 327065, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rtn1bprovided by ZNC
    Official Full Name
    reticulon 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030710-3
    See related
    Ensembl:ENSDARG00000021143 AllianceGenome:ZFIN:ZDB-GENE-030710-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rtn1; rtn1l; wu:fa21b09; wu:fj35h01
    Summary
    Predicted to be involved in brain development; endoplasmic reticulum tubular network formation; and neuron differentiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane; neuron projection; and postsynaptic density. Is expressed in central nervous system; eye; gill; heart; and muscle. Orthologous to human RTN1 (reticulon 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See rtn1b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (20637851..20695953)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (20737899..20796280)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-253p18.2 Neighboring gene uncharacterized LOC137488641 Neighboring gene RD3 like Neighboring gene ATP synthase membrane subunit j Neighboring gene protein phosphatase 1, regulatory subunit 13Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Targeting neural circuitry in zebrafish using GAL4 enhancer trapping. Scott EK, et al. Nat Methods, 2007 Apr. PMID 17369834
    2. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SF, et al. BMC Genomics, 2008 Apr 28. PMID 18442396, Free PMC Article
    3. Analysis of the reticulon gene family demonstrates the absence of the neurite growth inhibitor Nogo-A in fish. Diekmann H, et al. Mol Biol Evol, 2005 Aug. PMID 15858203
    4. A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. Oertle T, et al. FASEB J, 2003 Jul. PMID 12832288
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    reticulon-1b
    Names
    reticulon 1, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029948.2 → NP_001025119.1  reticulon-1b isoform 1

      See identical proteins and their annotated locations for NP_001025119.1

      Status: VALIDATED

      Source sequence(s)
      BX088722
      UniProtKB/TrEMBL
      A8E4S3, Q5TZI1
      Related
      ENSDARP00000009989.9, ENSDART00000027758.11
      Conserved Domains (1) summary
      pfam02453
      Location:27 → 189
      Reticulon; Reticulon

    2. NM_001328270.1 → NP_001315199.1  reticulon-1b isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX088722
      UniProtKB/TrEMBL
      A0A8M1P9Q6, Q4G5W6
      Related
      ENSDARP00000073534.4, ENSDART00000079079.6
      Conserved Domains (1) summary
      pfam02453
      Location:77 → 239
      Reticulon; Reticulon

    3. NM_001328271.1 → NP_001315200.1  reticulon-1b isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX088722
      UniProtKB/TrEMBL
      A0A8M1P3N9, F1R540
      Related
      ENSDARP00000060202.4, ENSDART00000060203.6
      Conserved Domains (1) summary
      pfam02453
      Location:582 → 744
      Reticulon; Reticulon

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      20637851..20695953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160490.5 → XP_005160547.1  reticulon-1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7D0
      Conserved Domains (2) summary
      PLN03131
      Location:39 → 410
      PLN03131; hypothetical protein; Provisional
      pfam02453
      Location:581 → 743
      Reticulon; Reticulon
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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