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    prpf3 PRP3 pre-mRNA processing factor 3 homolog (yeast) [ Danio rerio (zebrafish) ]

    Gene ID: 403072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prpf3provided by ZNC
    Official Full Name
    PRP3 pre-mRNA processing factor 3 homolog (yeast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040823-3
    See related
    Ensembl:ENSDARG00000086425 AllianceGenome:ZFIN:ZDB-GENE-040823-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    HPRP3; HPRP3P; wu:fa11f05
    Summary
    Acts upstream of or within retina development in camera-type eye. Predicted to be located in nucleus. Predicted to be part of U4/U6 x U5 tri-snRNP complex. Is expressed in head. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 18. Orthologous to human PRPF3 (pre-mRNA processing factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prpf3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (9432622..9453573, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (9541720..9562671, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene KIAA0947-like (H. sapiens) Neighboring gene chemokine (C-C motif) receptor 8.1 Neighboring gene uncharacterized LOC101884995 Neighboring gene uncharacterized LOC101884965

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Decreased levels of the RNA splicing factor Prpf3 in mice and zebrafish do not cause photoreceptor degeneration. Graziotto JJ, et al. Invest Ophthalmol Vis Sci, 2008 Sep. PMID 18552388
    2. Dysregulation of Spliceosomes Complex Induces Retinitis Pigmentosa-Like Characteristics in sf3b4-Depleted Zebrafish. Ulhaq ZS, et al. Am J Pathol, 2023 Sep. PMID 37263342
    3. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Jiang L, et al. Cell, 2013 May 9. PMID 23663777, Free PMC Article
    4. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish. Liu Y, et al. J Ophthalmol, 2015. PMID 26137319, Free PMC Article
    5. PRPF4 mutations cause autosomal dominant retinitis pigmentosa. Chen X, et al. Hum Mol Genet, 2014 Jun 1. PMID 24419317

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6 small nuclear ribonucleoprotein Prp3
    Names
    U4/U6-associated RNA splicing factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205748.2 → NP_991311.2  U4/U6 small nuclear ribonucleoprotein Prp3

      See identical proteins and their annotated locations for NP_991311.2

      Status: PROVISIONAL

      Source sequence(s)
      BC139603
      UniProtKB/TrEMBL
      A4QP06
      Related
      ENSDARP00000107223.2, ENSDART00000126154.4
      Conserved Domains (3) summary
      pfam01480
      Location:9 → 76
      PWI; PWI domain
      pfam06544
      Location:565 → 688
      DUF1115; Protein of unknown function (DUF1115)
      pfam08572
      Location:328 → 540
      PRP3; pre-mRNA processing factor 3 (PRP3)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      9432622..9453573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394953.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      81468..101722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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