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    mb myoglobin [ Danio rerio (zebrafish) ]

    Gene ID: 393558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mbprovided by ZNC
    Official Full Name
    myoglobinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1430
    See related
    Ensembl:ENSDARG00000031952 AllianceGenome:ZFIN:ZDB-GENE-040426-1430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:65819; zgc:77764
    Summary
    Predicted to enable several functions, including nitrite reductase activity; oxygen binding activity; and oxygen carrier activity. Acts upstream of or within several processes, including response to activity; response to hypoxia; and vasculogenesis. Predicted to be located in sarcoplasm. Is expressed in several structures, including cardiovascular system; digestive system; epithelial cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human MB (myoglobin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55137927..55145085)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54460281..54467434)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene SERTA domain containing 2a Neighboring gene RAB1A, member RAS oncogene family a Neighboring gene proliferation associated nuclear element Neighboring gene zgc:158803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and validation of a myoglobin knockout zebrafish model. Hejlesen R, et al. Transgenic Res, 2023 Dec. PMID 37847464, Free PMC Article
    2. Structural and kinetic characterization of myoglobins from eurythermal and stenothermal fish species. Madden PW, et al. Comp Biochem Physiol B Biochem Mol Biol, 2004 Mar. PMID 15050521
    3. Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish. Cossins AR, et al. J Exp Biol, 2009 Mar. PMID 19218513
    4. A critical role for myoglobin in zebrafish development. Vlecken DH, et al. Int J Dev Biol, 2009. PMID 19378255
    5. Molecular evolution of myoglobin in the Tibetan Plateau endemic schizothoracine fish (Cyprinidae, Teleostei) and tissue-specific expression changes under hypoxia. Qi D, et al. Fish Physiol Biochem, 2018 Apr. PMID 29230594

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and validation of a myoglobin knockout zebrafish model.
      Title: Generation and validation of a myoglobin knockout zebrafish model.
    2. myoglobin plays a crucial role in zebrafish development and is important for angiogenesis and gut development
      Title: A critical role for myoglobin in zebrafish development.
    3. Cell-specific distribution of Mb within non-muscle tissues in zebrafish plays an important role in the regulation of microvascular, renal and brain function.
      Title: Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65819

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxygen transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in removal of superoxide radicals ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myoglobin
    Names
    nitrite reductase MB
    pseudoperoxidase MB
    NP_001349318.1
    NP_001349319.1
    NP_956880.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362389.1 → NP_001349318.1  myoglobin

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      CU467849, DR716512
      UniProtKB/Swiss-Prot
      Q6P028, Q6VN46
      Related
      ENSDARP00000116402.1, ENSDART00000133472.3
      Conserved Domains (1) summary
      cl21461
      Location:2 → 147
      Globin_like; Globin-like proteins

    2. NM_001362390.1 → NP_001349319.1  myoglobin

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      CU467849, EH493828
      UniProtKB/Swiss-Prot
      Q6P028, Q6VN46
      Related
      ENSDARP00000120260.1, ENSDART00000138070.3
      Conserved Domains (1) summary
      cl21461
      Location:2 → 147
      Globin_like; Globin-like proteins

    3. NM_200586.2 → NP_956880.1  myoglobin

      See identical proteins and their annotated locations for NP_956880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      CU467849
      UniProtKB/Swiss-Prot
      Q6P028, Q6VN46
      Related
      ENSDARP00000120315.1, ENSDART00000136378.3
      Conserved Domains (1) summary
      cl21461
      Location:2 → 147
      Globin_like; Globin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      55137927..55145085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VN46.3 GenPept UniProtKB/Swiss-Prot:Q6VN46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.