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    sv2bb synaptic vesicle glycoprotein 2Bb [ Danio rerio (zebrafish) ]

    Gene ID: 100006427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sv2bbprovided by ZNC
    Official Full Name
    synaptic vesicle glycoprotein 2Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2789
    See related
    Ensembl:ENSDARG00000060711 AllianceGenome:ZFIN:ZDB-GENE-030131-2789
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sv2b; wu:fc17h05
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to act upstream of or within chemical synaptic transmission; neurotransmitter transport; and transmembrane transport. Predicted to be located in cytoplasmic vesicle; membrane; and synapse. Predicted to be active in synaptic vesicle membrane. Is expressed in central nervous system; lateral line ganglion; neurons; retinal ganglion cell layer; and retinal inner nuclear layer. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sv2bb in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (11037341..11088832, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (10940545..10992079, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene mesoderm posterior ab Neighboring gene mesoderm posterior bb Neighboring gene A-kinase anchoring protein 13 Neighboring gene AGBL carboxypeptidase 1 Neighboring gene ectodermal-neural cortex 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of vertebrate nicotinic acetylcholine receptors. Pedersen JE, et al. BMC Evol Biol, 2019 Jan 30. PMID 30700248, Free PMC Article
    2. Cellular expression of Smarca4 (Brg1)-regulated genes in zebrafish retinas. Hensley MR, et al. BMC Dev Biol, 2011 Jul 14. PMID 21756345, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptic vesicle glycoprotein 2B; synaptic vesicle glycoprotein 2Bb
    Names
    synaptic vesicle glycoprotein 2 b
    synaptic vesicle glycoprotein 2 bb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      11037341..11088832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161518.5 → XP_005161575.1  synaptic vesicle glycoprotein 2B

      UniProtKB/TrEMBL
      A0A8M2B8E2, X1WCQ3
      Related
      ENSDARP00000128000.1, ENSDART00000154748.2
      Conserved Domains (2) summary
      cd06174
      Location:115 → 308
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam13599
      Location:457 → 532
      Pentapeptide_4; Pentapeptide repeats (9 copies)
    Nucleotide Protein
    Heading Accession and Version

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