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    rnf130 ring finger protein 130 [ Danio rerio (zebrafish) ]

    Gene ID: 553950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnf130provided by ZNC
    Official Full Name
    ring finger protein 130provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-525
    See related
    Ensembl:ENSDARG00000089767 AllianceGenome:ZFIN:ZDB-GENE-050522-525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc14g02; zgc:113271
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rnf130 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (36765614..36863406, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (36425300..36523129, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene tryptophan 2,3-dioxygenase a Neighboring gene cathepsin O Neighboring gene si:ch211-132p1.2 Neighboring gene leukocyte cell derived chemotaxin 2, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF130
    Names
    goliath
    NP_001018301.2
    XP_009289393.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020465.2 → NP_001018301.2  E3 ubiquitin-protein ligase RNF130 precursor

      Status: VALIDATED

      Source sequence(s)
      BX005069, CR931784
      UniProtKB/TrEMBL
      A0A8N7XJ76, B2GPU6, E7FCE1, Q501T3
      Related
      ENSDARP00000134816.1, ENSDART00000158052.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      36765614..36863406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291118.4 → XP_009289393.1  E3 ubiquitin-protein ligase RNF130 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B0D3, A0A8N7XJ76, B2GPU6, E7FCE1, Q501T3
      Conserved Domains (2) summary
      cd02122
      Location:49 → 188
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:271 → 314
      zf-RING_2; Ring finger domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394922.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      145097..206281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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