trmt2a tRNA methyltransferase 2 homolog A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trmt2aprovided by ZNC
Official Full Name: tRNA methyltransferase 2 homolog Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6876
See related: Ensembl:ENSDARG00000002830 AllianceGenome:ZFIN:ZDB-GENE-030131-6876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: htf9c; fa10b06; zgc:55519; wu:fa10b06
Summary: Predicted to enable RNA binding activity and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Predicted to act upstream of or within RNA processing and methylation. Is expressed in several structures, including cerebellum; digestive system; midbrain; pectoral fin musculature; and retina. Orthologous to human TRMT2A (tRNA methyltransferase 2 homolog A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (24532401..24543526, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (24028601..24039726, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa10b06.s1 (e-PCR)
- UniSTS:202274

fc23f08.x1 (e-PCR)
- UniSTS:193160

fc23f08.x1 (e-PCR)
- UniSTS:187841

fc06d09.x1 (e-PCR)
- UniSTS:192249

fc06d09.x1 (e-PCR)
- UniSTS:192250

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: tRNA (uracil-5-)-methyltransferase homolog A

Names: HpaII tiny fragments locus 9c; trm2 tRNA methyltransferase 2 homolog A

NP_956223.1

EC 2.1.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199929.1 → NP_956223.1 tRNA (uracil-5-)-methyltransferase homolog A

See identical proteins and their annotated locations for NP_956223.1

Status: PROVISIONAL

Source sequence(s)

BC045367

UniProtKB/TrEMBL

Q7ZVY1

Related

ENSDARP00000046383.5, ENSDART00000046384.6

Conserved Domains (4) summary

COG0724
Location:71 → 160

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

COG2265
Location:201 → 604

TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]

cd12439
Location:69 → 147

RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins

cl17173
Location:410 → 610

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...