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    ppid peptidylprolyl isomerase D [ Danio rerio (zebrafish) ]

    Gene ID: 415155, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ppidprovided by ZNC
    Official Full Name
    peptidylprolyl isomerase Dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-34
    See related
    Ensembl:ENSDARG00000038835 AllianceGenome:ZFIN:ZDB-GENE-040625-34
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86711; wu:fb18b07
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within protein peptidyl-prolyl isomerization. Predicted to be active in cytosol. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ppid in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (48045193..48065365)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (49056540..49077608)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor 2b Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene sperm microtubule inner protein 2 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene relaxin family peptide receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Roca FJ, et al. Cell, 2013 Apr 25. PMID 23582643, Free PMC Article
    2. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Roca FJ, et al. Cell, 2019 Sep 5. PMID 31474371, Free PMC Article
    3. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Zhao S, et al. Proteomics, 2012 Jan. PMID 22140076
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase D
    NP_001002065.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002065.1 → NP_001002065.1  peptidyl-prolyl cis-trans isomerase D

      See identical proteins and their annotated locations for NP_001002065.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071388
      UniProtKB/TrEMBL
      A0A8M1MZT4, F1R5R3, Q6IQL7
      Related
      ENSDARP00000107677.2, ENSDART00000124773.4
      Conserved Domains (5) summary
      cd01926
      Location:16 → 182
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      sd00006
      Location:223 → 268
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:309 → 341
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:223 → 304
      TPR_11; TPR repeat
      pfam13424
      Location:271 → 340
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      48045193..48065365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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