ucp1 uncoupling protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ucp1provided by ZNC
Official Full Name: uncoupling protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010503-1
See related: Ensembl:ENSDARG00000023151 AllianceGenome:ZFIN:ZDB-GENE-010503-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: UCP3; UCPx; ucp4; fb62c08; zgc:55824; zgc:77603; wu:fb62c08
Summary: Predicted to enable oxidative phosphorylation uncoupler activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in membrane. Is expressed in several structures, including brain; heart; liver; median fin fold; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (53374488..53388911)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (52739750..52754173)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb62c08.x1 (e-PCR)
- UniSTS:203389

fb65c08 (e-PCR)
- UniSTS:189066

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial brown fat uncoupling protein 1

Names: uncoupling protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.