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    pola2 polymerase (DNA directed), alpha 2 [ Danio rerio (zebrafish) ]

    Gene ID: 322059, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pola2provided by ZNC
    Official Full Name
    polymerase (DNA directed), alpha 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-778
    See related
    Ensembl:ENSDARG00000015070 AllianceGenome:ZFIN:ZDB-GENE-030131-778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56124; zgc:77841; wu:fb48f05
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within with a positive effect on cell population proliferation and fin regeneration. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pola2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (17174795..17184516, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (17139083..17148804, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4 Neighboring gene centromere protein H Neighboring gene DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) Neighboring gene uncharacterized LOC137496333

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole-body clonal mapping identifies giant dominant clones in zebrafish skin epidermis. Roan HY, et al. Development, 2021 Sep 15. PMID 34463754
    2. The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Tseng TL, et al. Development, 2021 Aug 1. PMID 34323273, Free PMC Article
    3. Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Wang YT, et al. Curr Biol, 2019 Dec 16. PMID 31786062, Free PMC Article
    4. Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Mans DA, et al. J Pathol, 2013 Sep. PMID 23744542
    5. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within_positive_effect cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase alpha subunit B
    Names
    polymerase (DNA-directed), alpha (70kD)
    NP_955875.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199581.2 → NP_955875.2  DNA polymerase alpha subunit B

      Status: VALIDATED

      Source sequence(s)
      BC065460, BX465215, EH494906, EH521232, EH582754, EH606241
      UniProtKB/TrEMBL
      A0A8M1PBJ8, B0S687, Q6P0S9
      Related
      ENSDARP00000002618.6, ENSDART00000025803.7
      Conserved Domains (2) summary
      pfam04042
      Location:346 → 550
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:23 → 246
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      17174795..17184516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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