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    dcxr dicarbonyl/L-xylulose reductase [ Danio rerio (zebrafish) ]

    Gene ID: 550282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dcxrprovided by ZNC
    Official Full Name
    dicarbonyl/L-xylulose reductaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7002
    See related
    Ensembl:ENSDARG00000079271 AllianceGenome:ZFIN:ZDB-GENE-030131-7002
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa12f09; zgc:111977
    Summary
    Predicted to enable L-xylulose reductase (NADPH) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dcxr in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (3043303..3053545, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (3008575..3019006, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3b Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene sarcoglycan, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-xylulose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-xylulose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    L-xylulose reductase
    NP_001017619.1
    XP_005156041.1
    XP_068080694.1
    XP_068080695.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017619.1 → NP_001017619.1  L-xylulose reductase

      See identical proteins and their annotated locations for NP_001017619.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093141
      UniProtKB/TrEMBL
      A0A8M1N5D6, Q567K5
      Related
      ENSDARP00000019859.7, ENSDART00000023796.9
      Conserved Domains (2) summary
      PRK07060
      Location:1 → 243
      PRK07060; short chain dehydrogenase; Provisional
      cd05351
      Location:1 → 244
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      3043303..3053545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224594.1 → XP_068080695.1  L-xylulose reductase isoform X1

      UniProtKB/TrEMBL
      A0A8M1N5D6, Q567K5

    2. XM_068224593.1 → XP_068080694.1  L-xylulose reductase isoform X1

      UniProtKB/TrEMBL
      A0A8M1N5D6, Q567K5

    3. XM_005155984.5 → XP_005156041.1  L-xylulose reductase isoform X1

      See identical proteins and their annotated locations for XP_005156041.1

      UniProtKB/TrEMBL
      A0A8M1N5D6, Q567K5
      Related
      ENSDARP00000119912.1, ENSDART00000137148.3
      Conserved Domains (2) summary
      PRK07060
      Location:1 → 243
      PRK07060; short chain dehydrogenase; Provisional
      cd05351
      Location:1 → 244
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version

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