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    ppp1cab protein phosphatase 1, catalytic subunit, alpha isozyme b [ Danio rerio (zebrafish) ]

    Gene ID: 327301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp1cabprovided by ZNC
    Official Full Name
    protein phosphatase 1, catalytic subunit, alpha isozyme bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5512
    See related
    Ensembl:ENSDARG00000071566 AllianceGenome:ZFIN:ZDB-GENE-030131-5512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ppp1ca; fb18b03; fd20h04; zgc:55744; zgc:76940; wu:fb18b03; wu:fd20h04; wu:fl22a03
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within angiogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism. Orthologous to human PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppp1cab in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (13205955..13223449)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (13167652..13185146)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member IVb Neighboring gene pelota mRNA surveillance and ribosome rescue factor Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like Neighboring gene interferon regulatory factor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo genome editing using a high-efficiency TALEN system. Bedell VM, et al. Nature, 2012 Nov 1. PMID 23000899, Free PMC Article
    2. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. Le MT, et al. PLoS Genet, 2011 Sep. PMID 21935352, Free PMC Article
    3. A Systems Biology Approach to the Coordination of Defensive and Offensive Molecular Mechanisms in the Innate and Adaptive Host-Pathogen Interaction Networks. Wu CC, et al. PLoS One, 2016. PMID 26881892, Free PMC Article
    4. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
    5. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. Saddala MS, et al. BMC Genomics, 2020 Feb 7. PMID 32033529, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1, catalytic subunit, alpha isozyme b
    NP_997875.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212710.2 → NP_997875.1  protein phosphatase 1, catalytic subunit, alpha isozyme b

      See identical proteins and their annotated locations for NP_997875.1

      Status: VALIDATED

      Source sequence(s)
      AW423139, BC066693, BI983457, CT723486
      UniProtKB/TrEMBL
      Q6NY91, Q7ZVR3
      Related
      ENSDARP00000087338.4, ENSDART00000092906.6
      Conserved Domains (2) summary
      PTZ00480
      Location:6 → 321
      PTZ00480; serine/threonine-protein phosphatase; Provisional
      cd07414
      Location:8 → 298
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      13205955..13223449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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