cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cln3provided by ZNC
Official Full Name: CLN3 lysosomal/endosomal transmembrane protein, batteninprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-174
See related: Ensembl:ENSDARG00000037865 AllianceGenome:ZFIN:ZDB-GENE-041114-174
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92244
Summary: Acts upstream of or within axonogenesis; lysosome organization; and negative regulation of neuron apoptotic process. Predicted to be located in lysosomal membrane. Predicted to be active in lysosome. Is expressed in brain; central nervous system; cerebellum; and midbrain hindbrain boundary. Used to study neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (39262629..39599339)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (39437598..39457481)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLN3 deficiency leads to neurological and metabolic perturbations during early development.
Title: CLN3 deficiency leads to neurological and metabolic perturbations during early development.

Submit: New GeneRIF Correction

General gene information

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Markers

fc42f06.y1 (e-PCR)
- UniSTS:193828

fd36h03.x1 (e-PCR)
- UniSTS:195432

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: battenin

Names: ceroid-lipofuscinosis, neuronal 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.