leg1.1 liver-enriched gene 1, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: leg1.1provided by ZNC
Official Full Name: liver-enriched gene 1, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1178
See related: Ensembl:ENSDARG00000090722 AllianceGenome:ZFIN:ZDB-GENE-030131-1178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: leg1a; Leg1-A; wu:fb61h05; zgc:172246
Summary: Acts upstream of or within digestive system development; embryonic liver development; and liver development. Located in extracellular space. Is expressed in liver. Orthologous to human C6orf58 (chromosome 6 open reading frame 58). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (1412358..1421005)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (1391532..1400179)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Difference in an intermolecular disulfide-bond between two highly homologous serum proteins Leg1a and Leg1b implicates their functional differentiation.
Title: Difference in an intermolecular disulfide-bond between two highly homologous serum proteins Leg1a and Leg1b implicates their functional differentiation.
Leg1 plays a unique role in protecting liver development under different stress conditions by serving as a secreted signaling molecule/modulator.
Title: Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.
hif2-alpha-leg1 axis in liver development may have resulted from the adaptation of teleosts to their environment
Title: Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.
Data suggest that leg1a (NP_001093526.1) and leg1b (NP_998368.1) expression are differentially regulated.
Title: liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish.

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General gene information

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Markers

fb61h05 (e-PCR)
- UniSTS:187307

fd59d02.x1 (e-PCR)
- UniSTS:195755

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: liver-enriched gene 1, tandem duplicate 1

Names: leg1; liver-enriched gene protein 1-A; protein leg1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.