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    id4 inhibitor of DNA binding 4 [ Danio rerio (zebrafish) ]

    Gene ID: 664761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    id4provided by ZNC
    Official Full Name
    inhibitor of DNA binding 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051113-208
    See related
    Ensembl:ENSDARG00000045131 AllianceGenome:ZFIN:ZDB-GENE-051113-208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb547; fb77d04; sb:cb547; wu:fb77d04; zgc:123214
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within atrioventricular canal development; atrioventricular valve development; and regulation of Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; heart; and retina. Orthologous to human ID4 (inhibitor of DNA binding 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See id4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (9977858..9980363, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (10086956..10089897, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene grainyhead-like transcription factor 2a Neighboring gene neurocalcin delta a Neighboring gene uncharacterized LOC110437969 Neighboring gene uncharacterized LOC103908901

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis. Diotel N, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26107416
    2. Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development. Ahuja S, et al. Dev Biol, 2016 Apr 1. PMID 26892463
    3. Id2a is required for hepatic outgrowth during liver development in zebrafish. Khaliq M, et al. Mech Dev, 2015 Nov. PMID 26022495, Free PMC Article
    4. Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation. Kim S, et al. J Neurosci, 2012 Jun 13. PMID 22699901, Free PMC Article
    5. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Nachtrab G, et al. Development, 2013 Sep. PMID 23924636, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt signaling in the developing AVC endocardium
      Title: Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123214

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within atrioventricular canal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within atrioventricular valve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding protein inhibitor ID-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039990.1 → NP_001035079.1  DNA-binding protein inhibitor ID-4

      See identical proteins and their annotated locations for NP_001035079.1

      Status: PROVISIONAL

      Source sequence(s)
      BC108045
      UniProtKB/TrEMBL
      A0A8M1N8S2, Q32PN8
      Related
      ENSDARP00000066371.5, ENSDART00000066372.6
      Conserved Domains (1) summary
      smart00353
      Location:43 → 86
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      9977858..9980363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173489.2 → XP_005173546.1  DNA-binding protein inhibitor ID-4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKR8
      Conserved Domains (1) summary
      smart00353
      Location:43 → 86
      HLH; helix loop helix domain
    Nucleotide Protein
    Heading Accession and Version

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