mylpfa myosin light chain, phosphorylatable, fast skeletal muscle a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mylpfaprovided by ZNC
Official Full Name: myosin light chain, phosphorylatable, fast skeletal muscle aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990712-15
See related: Ensembl:ENSDARG00000053254 AllianceGenome:ZFIN:ZDB-GENE-990712-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb46; mlc2f; mylz2; myl11a; sb:cb46
Summary: Predicted to enable calcium ion binding activity. Involved in actin-myosin filament sliding and muscle tissue morphogenesis. Acts upstream of or within skeletal muscle tissue development. Predicted to be part of myosin complex. Predicted to be active in cytoplasm. Is expressed in caudal fin; esophagus; musculature system; segmental plate; and somite. Used to study distal arthrogryposis type 1A. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYL11 (myosin light chain 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32813048..32818536, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32681334..32686822, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Since we know so little about the molecules regulating vertebrate myocyte fusion, we propose that the mylpfa:H2B-GFP transgene will be a very useful reporter for conducting forward and reverse genetic screens to identify new components regulating vertebrate myocyte fusion.
Title: The zebrafish fast myosin light chain mylpfa:H2B-GFP transgene is a useful tool for in vivo imaging of myocyte fusion in the vertebrate embryo.
Data show a novel interaction between zebrafish Nanos and myosin light chain II (Mylz2).
Title: Zebrafish Nanos interacts with and regulates the phosphorylation of Mylz2.
mlc-2 gene is expressed in atrial and ventricular cardiomyocytes during early embryonic development, but also in the adult heart; cardiac MLC-2 is required for thick-filament stabilization and contractility in the vertebrate heart
Title: Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin-myosin filament sliding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin regulatory light chain 2, skeletal muscle isoform A

Names: fast skeletal myosin light chain 2; myosin light chain 11; myosin light chain 2; myosin regulatory light chain 11; myosin regulatory light chain 2, skeletal muscle; myosin, light polypeptide 2, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131188.2 → NP_571263.1 myosin regulatory light chain 2, skeletal muscle isoform A

See identical proteins and their annotated locations for NP_571263.1

Status: PROVISIONAL

Source sequence(s)

BC045520

UniProtKB/Swiss-Prot

O93409

Related

ENSDARP00000069948.4, ENSDART00000075465.5

Conserved Domains (1) summary

COG5126
Location:16 → 165

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]