pnp6 purine nucleoside phosphorylase 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pnp6provided by ZNC
Official Full Name: purine nucleoside phosphorylase 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1800
See related: Ensembl:ENSDARG00000040942 AllianceGenome:ZFIN:ZDB-GENE-040426-1800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77182
Summary: Predicted to enable purine-nucleoside phosphorylase activity. Predicted to act upstream of or within purine ribonucleoside salvage. Predicted to be active in cytoplasm. Is expressed in pronephros; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (21257261..21271373, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (21268195..21282307, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pentosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables purine-nucleoside phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables purine-nucleoside phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: purine nucleoside phosphorylase 6

NP_991218.2

EC 2.4.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205655.2 → NP_991218.2 purine nucleoside phosphorylase 6

Status: VALIDATED

Source sequence(s)

BX548070, CK028065

UniProtKB/TrEMBL

A0A8N7V076, Q1LWJ1

Related

ENSDARP00000060000.3, ENSDART00000060001.6

Conserved Domains (2) summary

COG0005
Location:16 → 286

XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]

PRK08202
Location:11 → 286

PRK08202; purine nucleoside phosphorylase; Provisional