adam19b ADAM metallopeptidase domain 19b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adam19bprovided by ZNC
Official Full Name: ADAM metallopeptidase domain 19bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-541
See related: Ensembl:ENSDARG00000067545 AllianceGenome:ZFIN:ZDB-GENE-070705-541
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adam19; si:dkeyp-44a8.1
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Is expressed in nervous system. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (6546487..6614057)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (6239721..6307330)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: disintegrin and metalloproteinase domain-containing protein 19

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_694823.10 → XP_699915.6 disintegrin and metalloproteinase domain-containing protein 19 isoform X1

UniProtKB/TrEMBL

A0A8N7TBW0, F1Q4N9

Related

ENSDARP00000087985.4, ENSDART00000097214.5

Conserved Domains (5) summary

smart00050
Location:461 → 525

DISIN; Homologues of snake disintegrins

smart00608
Location:527 → 674

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:236 → 432

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:236 → 434

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:74 → 185

Pep_M12B_propep; Reprolysin family propeptide
XM_068213295.1 → XP_068069396.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X2